Prof. Dr. Andreas Simm

Prof. Dr. Andreas Simm

Andreas Simm ist Biologe mit Schwerpunkt Biogerontologie. Nach seiner Dissertation zur altersabhängingen Wirkung von Onkogenen im Rattenmodel forschte er 10 Jahre zur Herzinsuffizienz im Alter. Im Jahr 2000 wurde er Forschungsleiter der Herzchirurgie und übernahm 2005 die Leitung des Zentrums für Medizinische Grundlagenforschung.

2010 gründetete er das Interdisziplinäre Zentrum für Altern in Halle (IZAH) und leitet es seitdem.

In der Universitätsmedizin ist er insbesondere für Altersmedizin zuständig.

  • Leiter Forschungslabor der Klinik für Herzchirurgie
  • Leiter des Zentrums für Medizinischen Grundlagenforschung
  • Leiter des Interdisziplinären Zentrums für Altern in Halle
  • stellv. Sprecher des Forschungsausschusses
  • Sprecher des Graduiertenkollegs DFG2155 ProMoAge
     
  • Präsident der Deutschen Gesellschaft für Gerontologie und Geriatrie
  • Sprecher der AG "Der alte Patient in der Herzchirurgie" der Deutschen Gesellschaft für Thorax-, Herz- und Gefäßchirurgie
  • Mitglied des Nukleus "Gerontokardiologie" der Deutschen Gesellschaft für Kardiologie
  • Altern des Herzkreislaufsystems
  • Proteinglykierung als Mechanismus des Alterns
  • Biomarker des gesunden Alterns
  • Functional Food

Übersicht Publikationen
Prof. Dr. rer. nat. Andreas Simm

  1. Fuellen G, Schofield P, Flatt T, Schulz RJ, Boege F, Kraft K, Rimbach G, Ibrahim S, Tietz A, Schmidt C, Köhling R, Simm A (2016) Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing. GERONTOLOGY, 62: 409-16
  2. Hussain M, Bork K, Gnanapragassam VS, Bennmann D, Jacobs K, Navarette-Santos A, Hofmann B, Simm A, Danker K, Horstkorte R (2016) Novel insights in the dysfunction of human blood-brain barrier after glycation. MECHANISMS OF AGEING AND DEVELOPMENT, 155: 48-54
  3. Navarrete Santos A, Yan J, Lochmann P, Pfeil H, Petersen M, Simm A, Treede H, Sievers HH, Mohamed SA (2016) Collagen analysis of the ascending aortic dilatation associated with bicuspid aortic valve disease compared with tricuspid aortic valve. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 122: 289-294
  4. Bär L, Wächter K, Wege N, Navarrete Santos A, Simm A, Föller M (2017) Advanced glycation end products stimulate gene expression of fibroblast growth factor 23. MOLECULAR NUTRITION & FOOD RESEARCH, 61: xy
  5. Bartling B, Al-Robaiy S, Lehnich H, Binder L, Hiebl B, Simm A (2017) Sex-related differences in the wheel-running activity of mice decline with increasing age. EXPERIMENTAL GERONTOLOGY, 87: 139-147
  6. Gergs U, Jung F, Buchwalow IB, Hofmann B, Simm A, Treede H, Neumann J (2017) Pharmacological and physiological assessment of serotonin formation and degradation in isolated preparations from mouse and human hearts. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 313: H1087-H1097
  7. Gielen S, Simm A (2017) Frailty and cardiac rehabilitation: A long-neglected connection. EUR J CARDIOV PREV R, 24: 1488-1489
  8. Lauenroth A, Schulze S, Ioannidis A, Simm A, Schwesig R (2017) Effect of an Age Simulation Suit on Younger Adults' Gait Performance Compared to Older Adults' Normal Gait. Research in Gerontological Nursing, 10: 227-233
  9. Martins MJ, Constância M, Neves D, Simm A (2017) Biomarkers of Aging: From Cellular Senescence to Age-Associated Diseases. Oxidative Medicine and Cellular Longevity, 2017: 7280690
  10. Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, Freer R, Fülöp T, Feige J, Gems D, Gladyshev V, Gorbunova V, Irincheeva I, Jager S, Jazwinski SM, Kaeberlein M, Kennedy B, Khaltourina D, Kovalchuk I, Kovalchuk O, Kozin S, Kulminski A, Lashmanova E, Lezhnina K, Liu GH, Longo V, Mamoshina P, Maslov A, Pedro de Magalhaes J, Mitchell J, Mitnitski A, Nikolsky Y, Ozerov I, Pasyukova E, Peregudova D, Popov V, Proshkina E, Putin E, Rogaev E, Rogina B, Schastnaya J, Seluanov A, Shaposhnikov M, Simm A, Skulachev V, Skulachev M, Solovev I, Spindler S, Stefanova N, Suh Y, Swick A, Tower J, Gudkov AV, Vijg J, Voronkov A, West M, Wagner W, Yashin A, Zemskaya N, Zhumadilov Z, Zhavoronkov A (2017) A review of the biomedical innovations for healthy longevity. AGING-US, 9: 7-25
  11. Nass N, Bayreuther K, Simm A (2017) Systemic activation of NF-κB driven luciferase activity in transgenic mice fed advanced glycation end products modified albumin. GLYCOCONJUGATE JOURNAL, 34: 157-161
  12. Navarrete Santos A, Jacobs K, Simm A, Glaubitz N, Horstkorte R, Hofmann B (2017) Dicarbonyls induce senescence of human vascular endothelial cells. MECHANISMS OF AGEING AND DEVELOPMENT, 166: 24-32
  13. Simm A, Sieber C (2017) Treatment of elderly patients: The challenge of the future. EXPERIMENTAL GERONTOLOGY, 87: 137-138
  14. Al-Robaiy S, Kindermann A, Wodischeck S, Simm A, Treede H, Bartling B (2018) Long-term endurance running activity causes pulmonary changes depending on the receptor for advanced glycation end-products. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 470: 1543-1553
  15. Gergs U, Rothkirch D, Hofmann B, Treede H, Robaye B, Simm A, Müller CE, Neumann J (2018) Mechanism underlying the contractile activity of UTP in the mammalian heart. EUROPEAN JOURNAL OF PHARMACOLOGY, 830: 47-58
  16. Hause F, Schlote D, Simm A, Hoffmann K, Santos AN (2018) Accumulation of glycated proteins suggesting premature ageing in lamin B receptor deficient mice. BIOGERONTOLOGY, 19: 95-100
  17. Hofmann B, Gmelin MJ, Metz D, Raspé C, Wienke A, Treede H, Simm A (2018) Cardiac surgery score (CASUS) improves outcome prediction in patients treated with extracorporal life support (ECLS). PERFUSION-UK, 33: 36-43
  18. Niemann B, Simm A, Rohrbach S (2018) Mechanisms Involved in Premature Aging in the Heart-Is There an Implication for Cardiac Surgery? THORACIC AND CARDIOVASCULAR SURGEON, 66: 31-41
  19. Bartling B, Niemann K, Pliquett RU, Treede H, Simm A (2019) Altered gene expression pattern indicates the differential regulation of the immune response system as an important factor in cardiac aging. EXPERIMENTAL GERONTOLOGY, 117: 13-20
  20. Bergau N, Maul S, Rujescu D, Simm A, Navarrete Santos A (2019) Reduction of Glycolysis Intermediate Concentrations in the Cerebrospinal Fluid of Alzheimer's Disease Patients. Frontiers in Neuroscience, 13: 871
  21. Ebert H, Lacruz ME, Kluttig A, Simm A, Greiser KH, Tiller D, Kartschmit N, Mikolajczyk R (2019) Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort. BMC Geriatrics, 19: 299
  22. Fuellen G, Jansen L, Cohen AA, Luyten W, Gogol M, Simm A, Saul N, Cirulli F, Berry A, Antal P, Köhling R, Wouters B, Möller S (2019) Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways. Aging and Disease, 10: 883-900
  23. Gergs U, Mangold W, Langguth F, Hatzfeld M, Hauptmann S, Bushnaq H, Simm A, Silber RE, Neumann J (2019) Alterations of protein expression of phospholamban, ZASP and plakoglobin in human atria in subgroups of seniors. Scientific Reports, 9: 5610
  24. Gergs U, Trapp T, Bushnaq H, Simm A, Silber RE, Neumann J (2019) Age-Dependent Protein Expression of Serine/Threonine Phosphatases and Their Inhibitors in the Human Cardiac Atrium. Adv Med, 2019: 2675972
  25. Höpfner F, Jacob M, Ulrich C, Russ M, Simm A, Silber RE, Girndt M, Noutsias M, Werdan K, Schlitt A (2019) Subgroups of monocytes predict cardiovascular events in patients with coronary heart disease. The PHAMOS trial (Prospective Halle Monocytes Study). Hellenic Journal of Cardiology, 60: 311-321
  26. Kindermann A, Baier J, Simm A, Haase R, Bartling B (2019) Receptor for advanced glycation end-products modulates lung development and lung sensitivity to hyperoxic injury in newborn mice. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 471: 983-994
  27. Kindermann A, Binder L, Baier J, Gündel B, Simm A, Haase R, Bartling B (2019) Severe but not moderate hyperoxia of newborn mice causes an emphysematous lung phenotype in adulthood without persisting oxidative stress and inflammation. BMC Pulmonary Medicine, 19: 245
  28. Seeling T, Haucke E, Navarrete Santos A, Grybel KJ, Gürke J, Pendzialek SM, Schindler M, Simm A, Navarrete Santos A (2019) Glyoxalase 1 expression is downregulated in preimplantation blastocysts of diabetic rabbits. REPRODUCTION IN DOMESTIC ANIMALS, 54 Suppl 3: 4-11
  29. Ye Z, Mittag S, Schmidt M, Simm A, Horstkorte R, Huber O (2019) Wnt Glycation Inhibits Canonical Signaling. Cells, 8: 1-2
  30. Bartling B, Zunkel K, Al-Robaiy S, Dehghani F, Simm A (2020) Gene doubling increases glyoxalase 1 expression in RAGE knockout mice. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1864: 129438
  31. Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T (2020) Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. MECHANISMS OF AGEING AND DEVELOPMENT, 191: 111316
  32. Ebert H, Lacruz ME, Kluttig A, Simm A, Greiser KH, Tiller D, Kartschmit N, Mikolajczyk R (2020) Association between advanced glycation end products, their soluble receptor, and mortality in the general population: Results from the CARLA study. EXPERIMENTAL GERONTOLOGY, 131: 110815
  33. Fuellen G, Liesenfeld O, Kowald A, Barrantes I, Bastian M, Simm A, Jansen L, Tietz-Latza A, Quandt D, Franceschi C, Walter M (2020) The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging). AGEING RESEARCH REVIEWS, 62: 101091
  34. Großkopf A, Simm A (2020) Carbohydrates in nutrition: friend or foe? ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 53: 290-294
  35. Hofmann B, Gerull KA, Bloch K, Riemer M, Erbs C, Fröhlich A, Richter S, Ehrhardt M, Zitterbart C, Bartel FF, Siegel P, Wienke A, Silber RE, Simm A (2020) It's all in our skin-Skin autofluorescence-A promising outcome predictor in cardiac surgery: A single centre cohort study. PLoS One, 15: e0234847
  36. Kindermann A, Binder L, Baier J, Gündel B, Simm A, Haase R, Bartling B (2020) Correction to: Severe but not moderate hyperoxia of newborn mice causes an emphysematous lung phenotype in adulthood without persisting oxidative stress and inflammation. BMC Pulmonary Medicine, 20: 17
  37. Klotz LO, Simm A (2020) [Aging and nutrition]. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 53: 283-284
  38. Korça E, Piskovatska V, Börgermann J, Navarrete Santos A, Simm A (2020) Circulating antibodies against age-modified proteins in patients with coronary atherosclerosis. Scientific Reports, 10: 17105
  39. Volk C, Brandsch C, Schlegelmilch U, Wensch-Dorendorf M, Hirche F, Simm A, Gargum O, Wiacek C, Braun PG, Kopp JF, Schwerdtle T, Treede H, Stangl GI (2020) Postprandial Metabolic Response to Rapeseed Protein in Healthy Subjects. NUTRIENTS, 12: 2270-2292
  40. Zunkel K, Simm A, Bartling B (2020) Long-term intake of the reactive metabolite methylglyoxal is not toxic in mice. FOOD AND CHEMICAL TOXICOLOGY, 141: 111333
  1. Barling B, Rehbein G, Somoza V, Silber RE, Simm A (2005) Maillard reaction productrich food impair cell proliferation and induce cell death in vitro. Signal Transduction, 6: 303-313
  2. Bartling B, Hofmann HS, Boettger T, Hansen G, Burdach S, Silber RE, Simm A (2005) Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma. LUNG CANCER, 49: 145-54.
  3. Bartling B, Hofmann HS, Weigle B, Silber RE, Simm A (2005) Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma. CARCINOGENESIS, 26: 293-201
  4. Czeslick EG, Nestler F, Simm A, Struppert A, Sablotzki A (2005) Drotrecogin alfa (activated) does not affect intracellular production of interleukin-6 and tumor necrosis factor-alpha in endotoxin-stimulated human monocytes. ANESTHESIA AND ANALGESIA, 101: 1805-8
  5. Ebelt H, Hufnagel N, Neuhaus P, Neuhaus H, Gajawada P, Simm A, Müller-Werdan U, Werdan K, Braun T (2005) Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis. CIRCULATION RESEARCH, 96: 509 - 517
  6. Galler AB, García Arguinzonis MI, Baumgartner W, Kuhn M, Smolenski A, Simm A, Reinhard M (2005) VASP-dependent regulation of actin cytoskeleton rigidity, cell adhesion, and detachment. HISTOCHEMISTRY AND CELL BIOLOGY, -: 1-18
  7. Hofmann HS, Hansen G, Richter G, Taege C, Simm A, Silber RE, Burdach S (2005) Matrix metalloproteinase-12 expression correlates with local recurrence and metastatic disease in non-small cell lung cancer patients. CLINICAL CANCER RESEARCH, 11: 1086-92
  8. Rohrbach S, Simm A, Pregla R, Franke C, Katschinski DM (2005) Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart. BIOGERONTOLOGY, 6: 165-71
  9. Bartling B, Demling N, Silber RE, Simm A (2006) Proliferative Stimulus of Lung Fibroblasts on Lung Cancer Cells is Impaired by RAGE. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 34: 83-91
  10. Bartling B, Rehbein G, Silber RE, Simm A (2006) Senescent fibroblasts induce moderate stress in lung epithelial cells in vitro. EXPERIMENTAL GERONTOLOGY, 41: 532-9
  11. Czeslick E, Struppert A, Simm A, Sablotzki A (2006) E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes. INFLAMMATION RESEARCH, 55: 511-5
  12. Gursinsky T, Ruhs S, Friess U, Diabaté S, Krug HF, Silber RE, Simm A (2006) Air pollution-associated fly ash particles induce fibrotic mechanisms in primary fibroblasts. BIOLOGICAL CHEMISTRY, 387: 1411-20
  13. Hofmann HS, Bartling B, Simm A, Murray R, Aziz N, Hansen G, Silber RE, Burdach S (2006) Identification and classification of differentially expressed genes in non-small cell lung cancer by expression profiling on a global human 59.620-element oligonucleotide array. ONCOLOGY REPORTS, 16: 587-95
  14. Krüger C, Köthe L, Struppert A, Pietruck C, Simm A, Grond S (2006) [Expression und function of the ORL-1 receptor on human leukocytes]. SCHMERZ, 20: 509-518
  15. Sablotzki A, Hentschel T, Hofmann S, Simm A, Mühling J, Czeslick E (2006) Inhaled aerosolized iloprost in the evaluation of heart transplant candidates--experiences with 45 cases. JOURNAL OF CLINICAL ANESTHESIA, 18: 108-13
  16. Scheubel RJ, Kahrstedt S, Weber H, Holtz J, Friedrich I, Borgermann J, Silber RE, Simm A (2006) Depression of progenitor cell function by advanced glycation endproducts (AGEs): potential relevance for impaired angiogenesis in advanced age and diabetes. EXPERIMENTAL GERONTOLOGY, 41: 540-8
  17. Simm A (2006) Cardiovascular ageing: a crosstalk between basic science and clinical practise is needed! EXPERIMENTAL GERONTOLOGY, 41: 459
  18. Bartling B, Desole M, Silber RE, Simm A (2007) Dicarbonyl-mediated protein modifications affect matrix metalloproteinase (MMP) activity. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 40: 357-61
  19. Bartling B, Fuchs C, Silber RE, Simm A (2007) Fibroblasts mediate induction of high mobility group box protein 1 in lung epithelial cancer cells by diffusible factors. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 20: 217-24
  20. Bartling B, Fuchs C, Somoza V, Niemann B, Silber RE, Simm A (2007) Lung level of HMBG1 is elevated in response to advanced glycation end product-enriched food in vivo. MOLECULAR NUTRITION & FOOD RESEARCH, 51: 479-87
  21. Bartling B, Rehbein G, Schmitt WD, Hofmann HS, Silber RE, Simm A (2007) S100A2-S100P expression profile and diagnosis of non-small cell lung carcinoma: impairment by advanced tumour stages and neoadjuvant chemotherapy. EUROPEAN JOURNAL OF CANCER, 43: 1935-43
  22. Börgermann J, Flohé S, Scheubel RJ, Kuss O, Simm A, Schade FU, Friedrich I (2007) Regulation of cytokine synthesis in cardiac surgery: Role of extracorporeal circuit and humoral mediators in vivo and in vitro. INFLAMMATION RESEARCH, 56: 126-32
  23. Börgermann J, Scheubel RJ, Simm A, Silber RE, Friedrich I (2007) Inflammatory response in on- versus off-pump myocardial revascularization: is ECC really the culprit? THORACIC AND CARDIOVASCULAR SURGEON, 55: 473-80
  24. Meißner C, Simm A (2007) Mechanismen des Alterns aus biogerontologischer Sicht: Neue Konzepte für die behandlung alter Patienten? ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 40: 311-313
  25. Nass N, Bartling B, Navarrete Santos A, Scheubel RJ, Börgermann J, Silber RE, Simm A (2007) Advanced glycation end products, diabetes and ageing. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 40: 349-356
  26. Ruhs S, Nass N, Somoza V, Friess U, Schinzel R, Silber RE, Simm A (2007) Maillard reaction products enriched food extract reduce the expression of myofibroblast phenotype markers. MOLECULAR NUTRITION & FOOD RESEARCH, 51: 488-95
  27. Simm A (2007) Book news: nutritional genomics - impact on health and disease. Edited by regina brigelius-flohé and hans-georg joost. MOLECULAR NUTRITION & FOOD RESEARCH, 51: 1555
  28. Simm A, Wagner J, Gursinsky T, Nass N, Friedrich I, Schinzel R, Czeslik E, Silber RE, Scheubel RJ (2007) Advanced glycation endproducts: a biomarker for age as an outcome predictor after cardiac surgery? EXPERIMENTAL GERONTOLOGY, 42: 668-75
  29. Bartling B, Hofmann HS, Silber RE, Simm A (2008) Differential impact of fibroblasts on the efficient cell death of lung cancer cells induced by paclitaxel and cisplatin. CANCER BIOLOGY & THERAPY, 7: -
  30. Brömme HJ, Zühlke L, Silber RE, Simm A (2008) DCFH2 interactions with hydroxyl radicals and other oxidants--influence of organic solvents. EXPERIMENTAL GERONTOLOGY, -: -
  31. Gergs U, Boknik P, Schmitz W, Simm A, Silber RE, Neumann J (2008) A positive inotropic effect of ATP in the human cardiac atrium. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 294: H1716-23
  32. Nass N, Schoeps R, Ulbrich-Hofmann R, Simm A, Hohndorf L, Schmelzer C, Raith K, Neubert RH, Eder K (2008) Screening for nutritive peptides that modify cholesterol 7alpha-hydroxylase expression. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56: 4987-94
  33. Rehbein G, Simm A, Hofmann HS, Silber RE, Bartling B (2008) Molecular regulation of S100P in human lung adenocarcinomas. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 22: 69-77
  34. Santos AN, Kahrstedt S, Nass N, Czeslick E, Scheubel RJ, Silber RE, Simm A (2008) Evidences for age-related modulation of human hematopoietic progenitor cell proliferation. EXPERIMENTAL GERONTOLOGY, 43: 1033-8
  35. Santos AN, Simm A, Holthoff V, Boehm G (2008) A method for the detection of amyloid-beta1-40, amyloid-beta1-42 and amyloid-beta oligomers in blood using magnetic beads in combination with Flow cytometry and its application in the diagnostics of Alzheimer's disease. JOURNAL OF ALZHEIMERS DISEASE, 14: 127-131
  36. Simm A, Friedrich I, Scheubel RJ, Gursinsky T, Silber RE, Bartling B (2008) Age dependency of the cariporide-mediated cardio-protection after simulated ischemia in isolated human atrial heart muscles. EXPERIMENTAL GERONTOLOGY, 43: 691-9
  37. Simm A, Nass N, Bartling B, Hoffmann B, Silber RE, Santos AN (2008) Potential biomarkers of ageing. BIOLOGICAL CHEMISTRY, 389: 257-65
  38. Simm A, Rando TA (2008) Tissue ageing: do insights into molecular mechanisms of ageing lead to new therapeutic strategies? EXPERIMENTAL GERONTOLOGY, 43: 603-4
  39. Barcelos LS, Duplaa C, Kränkel N, Graiani G, Invernici G, Katare R, Siragusa M, Meloni M, Campesi I, Monica M, Simm A, Campagnolo P, Mangialardi G, Stevanato L, Alessandri G, Emanueli C, Madeddu P (2009) Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. CIRCULATION RESEARCH, 104: 1095-102
  40. Bartling B, Desole M, Rohrbach S, Silber RE, Simm A (2009) Age-associated changes of extracellular matrix collagen impair lung cancer cell migration. FASEB JOURNAL, 23: 1510-20
  41. Boldt A, Gergs U, Frenker J, Simm A, Silber RE, Klöckner U, Neumann J (2009) Inotropic effects of L-lysine in the mammalian heart. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 380: 293-301
  42. Chen L, Frister A, Wang S, Ludwig A, Behr H, Pippig S, Li B, Simm A, Hofmann B, Pilowski C, Koch S, Buerke M, Rose-John S, Werdan K, Loppnow H (2009) Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 296: H987-96
  43. Cordes C, Bartling B, Simm A, Afar D, Lautenschläger C, Hansen G, Silber RE, Burdach S, Hofmann HS (2009) Simultaneous expression of Cathepsins B and K in pulmonary adenocarcinomas and squamous cell carcinomas predicts poor recurrence-free and overall survival. LUNG CANCER, 64: 79-85
  44. Friedrich I, Simm A, Kötting J, Thölen F, Fischer B, Silber RE (2009) Cardiac surgery in the elderly patient. Deutsches Arzteblatt International, 106: 416-22
  45. Gergs U, Boknik P, Schmitz W, Simm A, Silber RE, Neumann J (2009) A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 379: 533-40
  46. Gergs U, Neumann J, Simm A, Silber RE, Remmers FO, Läer S (2009) Phosphorylation of phospholamban and troponin I through 5-HT4 receptors in the isolated human atrium. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 379: 349-59
  47. Nass N, Kukat A, Seibel P, Brömme HJ, Schinzel R, Silber RE, Simm A (2009) Advanced glycation end product accumulation in rho(0) cells without a functional respiratory chain. BIOLOGICAL CHEMISTRY, 390: 915-9
  48. Bartling B, Koch A, Simm A, Scheubel R, Silber RE, Santos AN (2010) Insulin-like growth factor binding proteins-2 and -4 enhance the migration of human CD34-/CD133+ hematopoietic stem and progenitor cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 25: 89-96
  49. Bartling B, Rehbein G, Simm A, Silber RE, Hofmann HS (2010) Porcupine expression is associated with the expression of S100P and other cancer-related molecules in non-small cell lung carcinoma. INTERNATIONAL JOURNAL OF ONCOLOGY, 36: 1015-21
  50. Boldt A, Gergs U, Pönicke K, Simm A, Silber RE, Neumann J (2010) Inotropic effects of ivabradine in the mammalian heart. PHARMACOLOGY, 86: 249-58
  51. Müller-Werdan U, Blume H, Simm A (2010) Chancen(los) gegen die biologische Uhr? Im Fokus: das herz im Alter. MMW FORTSCHR MED, 152: 83-88
  52. Nass N, Vogel K, Hofmann B, Presek P, Silber RE, Simm A (2010) Glycation of PDGF results in decreased biological activity. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42: 749-54
  53. Ruhs S, Nass N, Bartling B, Brömme HJ, Leuner B, Somoza V, Friess U, Silber RE, Simm A (2010) Preconditioning with Maillard reaction products improves antioxidant defence leading to increased stress tolerance in cardiac cells. EXPERIMENTAL GERONTOLOGY, 45: 752-62
  54. Scheubel RJ, Holtz J, Friedrich I, Borgermann J, Kahrstedt S, Navarrete Santos A, Silber RE, Simm A (2010) Paracrine effects of CD34 progenitor cells on angiogenic endothelial sprouting. INTERNATIONAL JOURNAL OF CARDIOLOGY, 139: 134-41
  55. Simm A, Johnson TE (2010) Biomarkers of ageing: A challenge for the future. EXPERIMENTAL GERONTOLOGY, 45: 731-2
  56. Weidemann W, Klukas C, Klein A, Simm A, Schreiber F, Horstkorte R (2010) Lessons from GNE-deficient embryonic stem cells: sialic acid biosynthesis is involved in proliferation and gene expression. GLYCOBIOLOGY, 20: 107-17
  57. Bartling B, Hofmann HS, Sohst A, Hatzky Y, Somoza V, Silber RE, Simm A (2011) Prognostic potential and tumor growth-inhibiting effect of plasma advanced glycation end products in non-small cell lung carcinoma. MOLECULAR MEDICINE, 17: 980-9
  58. Bartling B, Simm A, Sohst A, Silber RE, Hofmann HS (2011) Effect of diabetes mellitus on the outcome of patients with resected non-small cell lung carcinoma. GERONTOLOGY, 57: 497-501
  59. Bartling B, Vanhooren V, Dewaele S, Libert C, Hofmann HS, Haerting J, Nuding S, Silber RE, Simm A, Chen CC (2011) Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma. Cancer Biomarkers, 10: 145-54
  60. Pöthig D, Simm A (2011) Brücken zwischen Experten schlagen: Vitalität, Gesundheitsressourcen und Biofunktionales Alter(n). B&G, 27: 57-63
  61. Pöthig D, Gerdes W, Viol M, Wagner P, Simm A (2011) [Biofunctional age diagnosis in humans. Potentials and limits]. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 44: 198-204
  62. Simm A (2011) [Vessel aging. The role of oxidative stress and protein glycation]. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 44: 146-52
  63. Simm A (2011) [Geriatrics: an introduction from a gerontological point of view]. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 136: 2549-53
  64. Lehnich H, Simm A, Weber B, Bartling B (2012) Development of a cyclic multi-axial Strain Cell Culture Device. Biomedical Engineering-Biomedizinische Technik, 57: 677-680
  65. Leuner B, Ruhs S, Brömme HJ, Bierhaus A, Sel S, Silber RE, Somoza V, Simm A, Nass N (2012) RAGE-dependent activation of gene expression of superoxide dismutase and vanins by AGE-rich extracts in mice cardiac tissue and murine cardiac fibroblasts. Food & Function, 3: 1091-8
  66. Leuner B, Max M, Thamm K, Kausler C, Yakobus Y, Bierhaus A, Sel S, Hofmann B, Silber RE, Simm A, Nass N (2012) RAGE influences obesity in mice. Effects of the presence of RAGE on weight gain, AGE accumulation, and insulin levels in mice on a high fat diet. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 45: 102-8
  67. Santos AN, Ewers M, Minthon L, Simm A, Silber RE, Blennow K, Prvulovic D, Hansson O, Hampel H (2012) Amyloid-β oligomers in cerebrospinal fluid are associated with cognitive decline in patients with Alzheimer's disease. JOURNAL OF ALZHEIMERS DISEASE, 29: 171-6
  68. Sel S, Schilling UM, Nass N, Simm A, Garreis F, Knak M, Storsberg J, Kaiser M, Kalinski T, Ehrich D, Bredehorn-Mayr T, Paulsen F (2012) Bone marrow cells and CD117-positive haematopoietic stem cells promote corneal wound healing. ACTA OPHTHALMOLOGICA, 90: e367-73
  69. Simm A (2012) [Diabetes. From a rare disease to a common illness]. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 45: 88-9
  70. Simm A, Navarrete-Santos A, Hofmann B, Bushnaq H, Nass N (2012) [Protein glycation as a pathological mechanism in diabetes]. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 45: 95-9
  71. Al-Robaiy S, Weber B, Simm A, Diez C, Rolewska P, Silber RE, Bartling B (2013) The receptor for advanced glycation end-products supports lung tissue biomechanics. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 305: L491-500
  72. Fuellen G, Boerries M, Busch H, de Grey A, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schäuble S, Simm A, Schofield PN, Smith B, Sühnel J, Vera J, Wagner W, Wönne EC, Wuttke D (2013) In silico approaches and the role of ontologies in aging research. REJUVENATION RESEARCH, 16: 540-6
  73. Hofmann B, Bushnaq H, Kraus FB, Raspé C, Simm A, Silber RE, Ludwig-Kraus B (2013) Immediate effects of individualized heparin and protamine management on hemostatic activation and platelet function in adult patients undergoing cardiac surgery with tranexamic acid antifibrinolytic therapy. PERFUSION-UK, 28: 412-8
  74. Hofmann B, Adam AC, Jacobs K, Riemer M, Erbs C, Bushnaq H, Simm A, Silber RE, Santos AN (2013) Advanced glycation end product associated skin autofluorescence: a mirror of vascular function? EXPERIMENTAL GERONTOLOGY, 48: 38-44
  75. Pötzsch S, Blankenhorn A, Navarrete Santos A, Silber RE, Somoza V, Simm A (2013) The effect of an AGE-rich dietary extract on the activation of NF-κB depends on the cell model used. Food & Function, 4: 1023-31
  76. Raspé C, Czeslick E, Weimann A, Schinke C, Leimert A, Kellner P, Simm A, Bucher M, Sablotzki A (2013) Glutamine and alanine-induced differential expression of intracellular IL-6, IL-8, and TNF-α in LPS-stimulated monocytes in human whole-blood. CYTOKINE, 62: 52-7
  77. Rolewska P, Al-Robaiy S, Navarrete Santos A, Simm A, Silber RE, Bartling B (2013) Age-related expression, enzymatic solubility and modification with advanced glycation end-products of fibrillar collagens in mouse lung. EXPERIMENTAL GERONTOLOGY, 48: 29-37
  78. Simm A (2013) [Communications of the DGGG (German Society of Gerontology and Geriatrics ). Report of the president]. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 46: 592
  79. Simm A (2013) Protein glycation during aging and in cardiovascular disease. Journal of Proteomics, 92: 248-59
  80. Simm A, Pitkälä KH (2013) Prevention and intervention. EXPERIMENTAL GERONTOLOGY, 48: 6-7
  81. Bennmann D, Horstkorte R, Hofmann B, Jacobs K, Navarrete-Santos A, Simm A, Bork K, Gnanapragassam VS (2014) Advanced glycation endproducts interfere with adhesion and neurite outgrowth. PLoS One, 9: e112115
  82. Fu H, Spieler F, Großmann J, Riemann D, Larisch M, Hiebl B, Schlecht K, Jaschke C, Bartling B, Hofmann B, Unverzagt S, Koch S, Pilowski C, Simm A, Silber RE, Gielen S, Seliger B, Schlitt A, Ebelt H, Müller-Werdan U, Buerke M, Werdan K, Loppnow H (2014) Interleukin-1 potently contributes to 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions. ATHEROSCLEROSIS, 237: 443-52
  83. Gergs U, Simm A, Bushnaq H, Silber RE, Neumann J (2014) A positive inotropic effect of UTP in the human cardiac atrium. EUROPEAN JOURNAL OF PHARMACOLOGY, 724: 24-30
  84. Giacconi R, Simm A, Santos AN, Costarelli L, Malavolta M, Mecocci P, Piacenza F, Basso A, Fulop T, Rink L, Dedoussis G, Kanoni S, Herbein G, Jajte J, Mocchegiani E (2014) Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation. Genes and Nutrition, 9: 426
  85. Gogol M, Hartmann H, Wustmann S, Simm A (2014) Influence of central nervous system-acting drugs on results of cognitive testing in geriatric inpatients. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 47: 279-84
  86. Haucke E, Navarrete Santos A, Simm A, Henning C, Glomb MA, Gürke J, Schindler M, Fischer B, Navarrete Santos A (2014) Accumulation of advanced glycation end products in the rabbit blastocyst under maternal diabetes. REPRODUCTION, 148: 169-78
  87. Haucke E, Navarrete-Santos A, Simm A, Silber RE, Hofmann B (2014) Glycation of extracellular matrix proteins impairs migration of immune cells. WOUND REPAIR AND REGENERATION, 22: 239-45
  88. Hofmann B, Riemer M, Erbs C, Plehn A, Navarrete Santos A, Wienke A, Silber RE, Simm A (2014) Carotid to femoral pulse wave velocity reflects the extent of coronary artery disease. Journal of Clinical Hypertension, 16: 629-33
  89. Hofmann B, Yakobus Y, Indrasari M, Nass N, Santos AN, Kraus FB, Silber RE, Simm A (2014) RAGE influences the development of aortic valve stenosis in mice on a high fat diet. EXPERIMENTAL GERONTOLOGY, 59: 13-20
  90. Nass N, Brömme HJ, Hartig R, Korkmaz S, Sel S, Hirche F, Ward A, Simm A, Wiemann S, Lykkesfeldt AE, Roessner A, Kalinski T (2014) Differential response to α-oxoaldehydes in tamoxifen resistant MCF-7 breast cancer cells. PLoS One, 9: e101473
  91. Nass N, Weissenberg K, Somoza V, Ruhs S, Silber RE, Simm A (2014) Cell culture condition-dependent impact of AGE-rich food extracts on kinase activation and cell survival on human fibroblasts. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 65: 219-25
  92. Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A (2014) Role of advanced glycation end products in cellular signaling. Redox Biology, 2: 411-29
  93. Rolewska P, Simm A, Silber RE, Bartling B (2014) Reduced expression level of the cyclic adenosine monophosphate response element-binding protein contributes to lung aging. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 50: 201-11
  94. Sel S, Nass N, Pötzsch S, Trau S, Simm A, Kalinski T, Duncker GI, Kruse FE, Auffarth GU, Brömme HJ (2014) UVA irradiation of riboflavin generates oxygen-dependent hydroxyl radicals. REDOX REPORT, 19: 72-9
  95. Simm A, Campisi J (2014) Stress and aging. EXPERIMENTAL GERONTOLOGY, 59: 1-2
  96. Simm A, Philipp C, Friedrich I, Scheubel RJ, Hofmann HS, Meibodi KH, Sablotzki A, Silber RE, Börgermann J (2014) Intraoperative sRAGE kinetics. A new age-related outcome predictor of cardiac surgery. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 47: 666-72
  97. Weber B, Bader N, Lehnich H, Simm A, Silber RE, Bartling B (2014) Microarray-based gene expression profiling suggests adaptation of lung epithelial cells subjected to chronic cyclic strain. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 33: 1452-66
  98. Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JHJ, Toussaint O, Grubeck-Loebenstein B, Mocchegiani E, Collino S, Gonos ES, Sikora E, Gradinaru D, Dollé M, Salmon M, Kristensen P, Griffiths HR, Libert C, Grune T, Breusing N, Simm A, Franceschi C, Capri M, Talbot D, Caiafa P, Friguet B, Slagboom PE, Hervonen A, Hurme M, Aspinall R (2015) MARK-AGE biomarkers of ageing. MECHANISMS OF AGEING AND DEVELOPMENT, 151: 2-12
  99. Gogol M, Simm A (2015) Stress: the good, the bad and the ugly? ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 48: 503-4
  100. Griffiths HR, Augustyniak EM, Bennett SJ, Debacq-Chainiaux F, Dunston CR, Kristensen P, Melchjorsen CJ, Navarrete SA, Simm A, Toussaint O (2015) Novel ageing-biomarker discovery using data-intensive technologies. MECHANISMS OF AGEING AND DEVELOPMENT, 151: 114-21
  101. Hofmann B, Jacobs K, Navarrete Santos A, Wienke A, Silber RE, Simm A (2015) Relationship between cardiac tissue glycation and skin autofluorescence in patients with coronary artery disease. DIABETES & METABOLISM, 41: 410-5
  102. Simm A (2015) Altern: Chancen und Risiken. Denkströme: Sächsische Akademie der Wissenschaften, 15: 117-126
  103. Simm A (2015) Wie alt bin ich wirklich? Die Diskrepanz zwischen kalendarischen und biologischen Alter. Aktuel Ernahrungsmed, 40: S23-S26
  104. Simm A, Klotz LO (2015) Stress and biological aging: A double-edged sword. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 48: 505-10
  105. Simm A, Müller B, Nass N, Hofmann B, Bushnaq H, Silber RE, Bartling B (2015) Protein glycation - Between tissue aging and protection. EXPERIMENTAL GERONTOLOGY, 68: 71-5
  106. Vanhooren V, Navarrete Santos A, Voutetakis K, Petropoulos I, Libert C, Simm A, Gonos ES, Friguet B (2015) Protein modification and maintenance systems as biomarkers of ageing. MECHANISMS OF AGEING AND DEVELOPMENT, 151: 71-84
  1. Elepfandt A, Simm A (1985) Water wave taxis in the yellow-bellied toad, bombina variegata L., evidence for lateral line function. Biology of Behavior, 10: 333-341
  2. Adam G, Simm A, Braun F (1987) Level of ribosomal RNA required for stimulation from quiescence increases during cellular aging in vitro of mammalian fibroblasts. EXPERIMENTAL CELL RESEARCH, 169: 345-56
  3. Simm A, Hoppe V, Tatje D, Schenzinger A, Hoppe J (1992) PDGF-AA effectively stimulates early events but has no mitogenic activity in AKR-2B mouse fibroblasts. EXPERIMENTAL CELL RESEARCH, 201: 192-9
  4. Hoppe J, Hoppe V, Karenberg TA, Fenn A, Simm A, Sachinidis A (1994) Differential activation by platelet-derived growth factor-BB of mitogen activated protein kinases in starved or nonstarved AKR-2B fibroblasts. JOURNAL OF CELLULAR PHYSIOLOGY, 161: 342-50
  5. Simm A, Halle JP, Adam G (1994) Proliferative and metabolic capacity of rat embryo fibroblasts immortalized by c-myc depends on cellular age at oncogenic transfection. EUROPEAN JOURNAL OF CELL BIOLOGY, 65: 121-31
  6. Simm A, Hoppe V, Gazit A, Hoppe J (1994) Platelet-derived growth factor isoforms prevent cell death during starvation of AKR-2B fibroblasts. JOURNAL OF CELLULAR PHYSIOLOGY, 160: 295-302
  7. Simm A, Karenberg TA, Hoppe V, Hoppe J (1994) Okadaic acid blocks PDGF-induced proliferation of AKR-2B fibroblasts at the transition from G1- to S-phase. EXPERIMENTAL CELL RESEARCH, 210: 160-5
  8. Leicht M, Simm A, Bertsch G, Hoppe J (1996) Okadaic acid induces cellular hypertrophy in AKR-2B fibroblasts: involvement of the p70S6 kinase in the onset of protein and rRNA synthesis. CELL GROWTH DIFFER, 7: 1199-209
  9. Halle JP, Müller S, Simm A, Adam G (1997) Copy number, epigenetic state and expression of the rRNA genes in young and senescent rat embryo fibroblasts. EUROPEAN JOURNAL OF CELL BIOLOGY, 74: 281-8
  10. Simm A, Bertsch G, Frank H, Zimmermann U, Hoppe J (1997) Cell death of AKR-2B fibroblasts after serum removal: a process between apoptosis and necrosis. JOURNAL OF CELL SCIENCE, 110: 819-28
  11. Simm A, Münch G, Seif F, Schenk O, Heidland A, Richter H, Vamvakas S, Schinzel R (1997) Advanced glycation endproducts stimulate the MAP-kinase pathway in tubulus cell line LLC-PK1. FEBS LETTERS, 410: 481-4
  12. Simm A, Nestler M, Hoppe V (1997) PDGF-AA, a potent mitogen for cardiac fibroblasts from adult rats. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 29: 357-68
  13. Dietrich G, Bubert A, Gentschev I, Sokolovic Z, Simm A, Catic A, Kaufmann SH, Hess J, Szalay AA, Goebel W (1998) Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes. NATURE BIOTECHNOLOGY, 16: 181-5
  14. Diez C, Simm A (1998) Gene expression in rod shaped cardiac myocytes, sorted by flow cytometry. CARDIOVASCULAR RESEARCH, 40: 530-7
  15. Heidland A, Schinzel R, Sebekova K, Xiang G, Münch G, Simm A (1998) Advanced glycation endproducts and the kidney. Przegl Lek, 55: 29-31
  16. Ling H, Ardjomand P, Samvakas S, Simm A, Busch GL, Lang F, Sebekova K, Heidland A (1998) Mesangial cell hypertrophy induced by NH4Cl: role of depressed activities of cathepsins due to elevated lysosomal pH. KIDNEY INTERNATIONAL, 53: 1706-12
  17. Raffelsbauer D, Bubert A, Engelbrecht F, Scheinpflug J, Simm A, Hess J, Kaufmann SH, Goebel W (1998) The gene cluster inlC2DE of Listeria monocytogenes contains additional new internalin genes and is important for virulence in mice. MOL GEN GENET, 260: 144-58
  18. Sebeková K, Schinzel R, Ling H, Simm A, Xiang G, Gekle M, Münch G, Vamvakas S, Heidland A (1998) Advanced glycated albumin impairs protein degradation in the kidney proximal tubules cell line LLC-PK1. CELLULAR AND MOLECULAR BIOLOGY, 44: 1051-60
  19. Simm A, Hoppe V, Karbach D, Leicht M, Fenn A, Hoppe J (1998) Late signals from the PDGF receptors leading to the activation of the p70S6-kinase are necessary for the transition from G1 to S phase in AKR-2B cells. EXPERIMENTAL CELL RESEARCH, 244: 379-93
  20. Simm A, Nestler M, Hoppe V (1998) Mitogenic effect of PDGF-AA on cardiac fibroblasts. BASIC RESEARCH IN CARDIOLOGY, 93: 40-3
  21. Simm A, Schlüter K, Diez C, Piper HM, Hoppe J (1998) Activation of p70(S6) kinase by beta-adrenoceptor agonists on adult cardiomyocytes. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 30: 2059-67
  22. Aulbach F, Simm A, Maier S, Langenfeld H, Walter U, Kersting U, Kirstein M (1999) Insulin stimulates the L-type Ca2+ current in rat cardiac myocytes. CARDIOVASCULAR RESEARCH, 42: 113-20
  23. Bubert A, Sokolovic Z, Chun SK, Papatheodorou L, Simm A, Goebel W (1999) Differential expression of Listeria monocytogenes virulence genes in mammalian host cells. MOL GEN GENET, 261: 323-36
  24. Diez C, Bertsch G, Simm A (1999) Isolation of full-size mRNA from cells sorted by flow cytometry. J BIOCHEM BIOPH METH, 40: 69-80
  25. Maier S, Aulbach F, Simm A, Lange V, Langenfeld H, Behre H, Kersting U, Walter U, Kirstein M (1999) Stimulation of L-type Ca2+ current in human atrial myocytes by insulin. CARDIOVASCULAR RESEARCH, 44: 390-7
  26. Rudolph C, Adam G, Simm A (1999) Determination of copy number of c-Myc protein per cell by quantitative Western blotting. ANALYTICAL BIOCHEMISTRY, 269: 66-71
  27. Schlüter KD, Simm A, Schäfer M, Taimor G, Piper HM (1999) Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy. AM J PHYSIOL, 276(5 Pt 2): H1655-63
  28. Simm A, Diez C (1999) Density dependent expression of PDGF-A modulates the angiotensin II dependent proliferation of rat cardiac fibroblasts. BASIC RESEARCH IN CARDIOLOGY, 94: 464-71
  29. Schoppet M, Huppertz HI, Simm A, Bubert A (2000) Infection of dendritic cells by enterobacteriaceae. MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 188: 191-6
  30. Bauer B, Krumböck N, Fresser F, Hochholdinger F, Spitaler M, Simm A, Uberall F, Schraven B, Baier G (2001) Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 276: 31627-34
  31. Brede M, Hadamek K, Meinel L, Wiesmann F, Peters J, Engelhardt S, Simm A, Haase A, Lohse MJ, Hein L (2001) Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT(2) receptor. CIRCULATION, 104: 2602-7.
  32. Daoud S, Schinzel R, Neumann A, Loske C, Fraccarollo D, Diez C, Simm A (2001) Advanced glycation endproducts: activators of cardiac remodeling in primary fibroblasts from adult rat hearts. MOLECULAR MEDICINE, 7: 543-51
  33. Diez C, Nestler M, Friedrich U, Vieth M, Stolte M, Hu K, Hoppe J, Simm A (2001) Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation. CARDIOVASCULAR RESEARCH, 49: 731-40
  34. Maier S, Lange V, Simm A, Walter U, Kirstein M (2001) Insulin fails to modulate the cardiac L-type Ca2+ current in Type II diabetes patients--a possible link to cardiac dysfunction in diabetes mellitus. DIABETOLOGIA, 44: 269
  35. Marienfeld U, Walter U, Simm A (2001) Inhibition of rat cardiac fibroblast growth by cAMP--but not by cGMP-dependent protein kinase. BASIC RESEARCH IN CARDIOLOGY, 96: 184-91
  36. Sablotzki A, Mann V, Friedrich I, Simm A, Czeslick E, Mühling J, Silber RE (2001) Influence of heparin-coated surfaces on lymphocyte-populations and acute-phase-response in patients with MODS following cardiopulmonary bypass surgery. THORACIC AND CARDIOVASCULAR SURGEON, 36: 24
  37. Sablotzki A, Mann V, Simm A, Czeslick E (2001) [Changes in the cytokine network through escalating SIRS after heart surgery.]. ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE, 36: 552-9.
  38. Scheubel RJ, Bartling B, Simm A, Drogaris K, Silber RE, Darmer D, Holtz J (2001) Activation of apoptotic initiator caspases and downregulation of endogenous caspase inhibitors but no seizable effector caspase-3 activation in terminally failing human hearts. CIRCULATION, 104: 738
  39. Scheubel RJ, Bartling B, Simm A, Silber RE, Drogaris K, Darmer D, Holtz J (2001) Activation of apoptotic initiator caspases and downregulation of endegenous inhibitors of apoptosis in terminally failing human hearts. EUROPEAN JOURNAL OF HEART FAILURE, 3: S66-67
  40. Scheubel RJ, Bartling B, Simm A, Silber RE, Drogaris K, Darmer D, Holtz J (2001) Activation of apoptotic initiator caspases and downregulation of endogenous caspase inhibitors but no seizable effector caspase-3 activation in terminally failing hearts. CIRCULATION, 104: II-738
  41. Xiang G, Schinzel R, Simm A, Münch G, Sebekova K, Kasper M, Niwa T, Schmitz C, Heidland A (2001) Advanced glycation end products (AGEs)-induced expression of TGF-beta 1 is suppressed by a
  42. protease in the tubule cell line LLC-PK1. NEPHROLOGY DIALYSIS TRANSPLANTATION, 16: 1562-9
  43. Xiang G, Schinzel R, Simm A, Sebekova K, Heidland A (2001) Advanced glycation end products impair protein turnover in LLC-PK1: amelioration by trypsin. KIDNEY INTERNATIONAL, 78: S:53-57
  44. Garcia Arguinzonis MI, Galler AB, Walter U, Reinhard M, Simm A (2002) Increased spreading, Rac/p21-activated kinase (PAK) activity, and compromised cell motility in cells deficient in vasodilator-stimulated phosphoprotein (VASP). JOURNAL OF BIOLOGICAL CHEMISTRY, 277: 45604-10.
  45. Hofmann HS, Simm A, Hammer A, Silber RE, Bartling B (2002) Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 128: 554-60.
  46. Scheubel RJ, Bartling B, Simm A, Silber RE, Drogaris K, Darmer D, Holtz J (2002) Aktivierung der Apoptosekaskade durch Mitochondrien und Todesrezeptoren ohne Caspase-3 Aktivierung im terminal insuffizienten Myokrad: fragile Balance des Myozy-tenüberlebens? Z KARDIOL, 91: 50
  47. Scheubel RJ, Bartling B, Simm A, Silber RE, Drogaris K, Darmer D, Holtz J (2002) Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium: fragile balance of myocyte survival? JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39: 481-8
  48. Scheubel RJ, Tostlebe M, Simm A, Rohrbach S, Prondzinsky R, Gellerich FN, Silber RE, Holtz J (2002) Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 40: 2174-81
  49. Soling A, Simm A, Rainov N (2002) Intracellular localization of Herpes simplex virus type 1 thymidine kinase fused to different fluorescent proteins depends on choice of fluorescent tag. FEBS LETTERS, 527: 153-8.
  50. Bartling B, Friedrich I, Silber RE, Simm A (2003) Ischemic preconditioning is not cardioprotective in senescent human myocardium. ANNALS OF THORACIC SURGERY, 76: 105-11.
  51. Bartling B, Hilgefort C, Friedrich I, Silber RE, Simm A (2003) Cardio-protective determinants are conserved in aged human myocardium after ischemic preconditioning. FEBS LETTERS, 555: 539-44.
  52. Czeslick EG, Simm A, Grond S, Silber RE, Sablotzki A (2003) Inhibition of intracellular tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 production in human monocytes by iloprost. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 33: 1013-7.
  53. Czeslick E, Simm A, Grond S, Silber RE, Radke J, Sablotzki A (2003) Age independent inhibition of tumour necrosis factor a (TNF-a) and interleukin 6 (IL-6) expression in human monocytes by iloprost. INFECTION, 31: 287
  54. Nestler F, Czeslick E, Simm A, Schinke C, Sablotzki A (2003) Berinert as C1-esterase-inhibition induces reduction of synthesis of cytokine IL-6 in human monocytes dependent on concentration. INFECTION, 31: 286
  55. Röntgen P, Czeslick E, Simm A, Hofmann S, Sablotzki A (2003) Influence of norepinephrine on the intracellular cytokine expression in monocytes. INFECTION, 31: 285
  56. Scheubel RJ, Zorn H, Silber RE, Kuss O, Morawietz H, Holtz J, Simm A (2003) Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 42: 2073-80.
  57. Schinke C, Czeslick E, Nestler F, Struppert A, Simm A, Sablotzki A (2003) Immunomodulatory effects of L-Glutamine on intracellular cytokine synthesis of human monocytes. INFECTION, 31: 292
  58. Casselmann C, Reimann A, Friedrich I, Schubert A, Silber RE, Simm A (2004) Age-dependent expression of advanced glycation end product receptor genes in the human heart. GERONTOLOGY, 50: 127-34
  59. Hofmann HS, Hansen G, Burdach S, Bartling B, Silber RE, Simm A (2004) Discrimination of human lung neoplasm from normal lung by two target genes. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 170: 516-9
  60. Röntgen P, Sablotzki A, Simm A, Silber RE, Czeslick E (2004) Effect of catecholamines on intracellular cytokine synthesis in human monocytes. EUROPEAN CYTOKINE NETWORK, 15: 14-23
  61. Simm A (2004) Altern: medizinisches Versagen oder biologische Notwendigkeit? Kardiotechnik, 13: 109-112
  62. Simm A, Bartling B, Silber RE (2004) RAGE: a new pleiotropic antagonistic gene? Annals of the New York Academy of Sciences, 1019: 228-31
  63. Simm A, Casselmann C, Schubert A, Hofmann S, Reimann A, Silber RE (2004) Age associated changes of AGE-receptor expression: RAGE upregulation is associated with human heart dysfunction. EXPERIMENTAL GERONTOLOGY, 39: 407-13
  64. Barling B, Rehbein G, Somoza V, Silber RE, Simm A (2005) Maillard reaction productrich food impair cell proliferation and induce cell death in vitro. Signal Transduction, 6: 303-313
  65. Bartling B, Hofmann HS, Boettger T, Hansen G, Burdach S, Silber RE, Simm A (2005) Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma. LUNG CANCER, 49: 145-54.
  66. Bartling B, Hofmann HS, Weigle B, Silber RE, Simm A (2005) Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma. CARCINOGENESIS, 26: 293-201
  67. Czeslick EG, Nestler F, Simm A, Struppert A, Sablotzki A (2005) Drotrecogin alfa (activated) does not affect intracellular production of interleukin-6 and tumor necrosis factor-alpha in endotoxin-stimulated human monocytes. ANESTHESIA AND ANALGESIA, 101: 1805-8
  68. Ebelt H, Hufnagel N, Neuhaus P, Neuhaus H, Gajawada P, Simm A, Müller-Werdan U, Werdan K, Braun T (2005) Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis. CIRCULATION RESEARCH, 96: 509 - 517
  69. Galler AB, García Arguinzonis MI, Baumgartner W, Kuhn M, Smolenski A, Simm A, Reinhard M (2005) VASP-dependent regulation of actin cytoskeleton rigidity, cell adhesion, and detachment. HISTOCHEMISTRY AND CELL BIOLOGY, -: 1-18
  70. Hofmann HS, Hansen G, Richter G, Taege C, Simm A, Silber RE, Burdach S (2005) Matrix metalloproteinase-12 expression correlates with local recurrence and metastatic disease in non-small cell lung cancer patients. CLINICAL CANCER RESEARCH, 11: 1086-92
  71. Rohrbach S, Simm A, Pregla R, Franke C, Katschinski DM (2005) Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart. BIOGERONTOLOGY, 6: 165-71
  1. Lehnich H, Simm A (2010) Erfassung ungezwungener Bewegungsprofile bei Labormäusen im Dauerversuch. In: Rahman,Jamal;Heinze,Ronald (Hg.) Virtuelle Instrumente in der Praxis 2010. VDE Verlag, Berlin, 449-452
  2. Simm A (2015) Kernthemen und Konzepte der Biogerontologie. In: Wahl, Hans-Werner; Heyl, Vera (Hg.) Gerontologie: Einführung und Geschichte. Kohlhammer Verlag, Stuttgart, 147-154
  3. Hedtke-Becker A, Simm A, Gogol M, Thiesemann R, Haendeler J, Czypiorsky P, Altschmied J, Swoboda W, Zimprich D, Aner K, Kricheldorff C (2016) Implemetierungswissenschaft in Deutschland: Ein Statement der DGGG. In: Hoben, Matthias; Bär, Marion; Wahl, Hans-Werner (Hg.) Implementierungswissenschaft für Pflege und Gerontologie. Kohlhammer Verlag, Stuttgart, 371-386
  4. Simm A, Seliger B, Klotz LO (2016) Cellular Aging and Tumor regulation. In: Rattan Suresh I.S.; Hayflick Leonhard (Hg.) Healthy Ageing and Longevity 4: Cellular Ageing and Replicative Senescence. Springer, Heidelberg, 187-201

 

Prof. Dr. Andreas Simm

Einrichtungen

Forschungslabor der Universitäts- und Poliklinik für Herzchirurgie Zentrum für Medizinische Grundlagenforschung (ZMG) Interdisziplinäres Zentrum für Altern Halle (IZAH) GRK 2155 ProMoAge - Proteinmodifikationen: Schlüsselmechanismen des Alterns