Publications

Halilovic M, Abdelsalam M, Zabkiewicz J, Lazenby M, Alvares C, Schmidt M, Brenner W, Najafi S, Oehme I, Hieber C, Zeyn Y, Bros M, Sippl W, Krämer OH. Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins. Leukemia. 2024 Sep 17. doi.org/10.1038/s41375-024-02405-5. PMID: 39300221.

Hase N, Misiak D, Taubert H, Hüttelmaier S, Gekle M, Köhn M. APOBEC3C-mediated NF-κB activation enhances clear cell renal cell carcinoma progression. Mol Oncol. 2024 Aug 26. doi.org/10.1002/1878-0261.13721. Epub ahead of print. PMID: 39183666.

Alfayomy AM, Ashry R, Kansy AG, Sarnow AC, Erdmann F, Schmidt M, Krämer OH, Sippl W. Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the ataxia telangiectasia and RAD3-related (ATR) kinase. Eur J Med Chem. 2024 Mar 5;267:116167. doi.org/10.1016/j.ejmech.2024.116167. Epub 2024 Jan 29. PMID: 38308949.

Wedler A, Bley N, Glaß M, Müller S, Rausch A, Lederer M, Urbainski J, Schian L, Obika KB, Simon T, Peters LM, Misiak C, Fuchs T, Köhn M, Jacob R, Gutschner T, Ihling C, Sinz A, Hüttelmaier S. RAVER1 hinders lethal EMT and modulates miR/RISC activity by the control of alternative splicing. Nucleic Acids Res. 2024 Feb 1:gkae046. doi.org/10.1093/nar/gkae046. Epub ahead of print. PMID: 38300787.

  1. Glaß M, Hüttelmaier S. IGF2BP1-An Oncofetal RNA-Binding Protein Fuels Tumor Virus Propagation. Viruses. 2023 Jun 24;15(7):1431. doi.org/10.3390/v15071431. PMID: 37515119; PMCID: PMC10385356.

  2. Hagemann S, Misiak D, Bell JL, Fuchs T, Lederer MI, Bley N, Hämmerle M, Ghazy E, Sippl W, Schulte JH, Hüttelmaier S. IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression. Mol Cancer. 2023 May 29;22(1):88. doi.org/10.1186/s12943-023-01792-0. PMID: 37246217; PMCID: PMC10226260.

  3. Bertoldo JB, Müller S, Hüttelmaier S. RNA-binding proteins in cancer drug discovery. Drug Discov Today. 2023 Jun;28(6):103580. doi.org/10.1016/j.drudis.2023.103580. Epub 2023 Apr 7. PMID: 37031812.