Publications

1. Glaß M, Hüttelmaier S. IGF2BP1-An Oncofetal RNA-Binding Protein Fuels Tumor Virus Propagation. Viruses. 2023 Jun 24;15(7):1431. doi.org/10.3390/v15071431. PMID: 37515119; PMCID: PMC10385356.

2. Hagemann S, Misiak D, Bell JL, Fuchs T, Lederer MI, Bley N, Hämmerle M, Ghazy E, Sippl W, Schulte JH, Hüttelmaier S. IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression. Mol Cancer. 2023 May 29;22(1):88. doi.org/10.1186/s12943-023-01792-0. PMID: 37246217; PMCID: PMC10226260.

3. Otte M, Stachelscheid J, Glaß M, Wahnschaffe L, Jiang Q, Lone W, Ianevski A, Aittokallio T, Iqbal J, Hallek M, Hüttelmaier S, Schrader A, Braun T, Herling M. The miR-141/200c-STAT4 Axis Contributes to Leukemogenesis by Enhancing Cell Proliferation in T-PLL. Cancers (Basel). 2023 Apr 28;15(9):2527. doi.org/10.3390/cancers15092527. PMID: 37173993; PMCID: PMC10177500.

4. Arndt L, Lindhorst A, Neugebauer J, Hoffmann A, Hobusch C, Alexaki VI, Ghosh A, Blüher M, Wolfrum C, Glaß M, Gericke M. The Role of IL-13 and IL-4 in Adipose Tissue Fibrosis. Int J Mol Sci. 2023 Mar 16;24(6):5672. doi.org/10.3390/ijms24065672. PMID: 36982747; PMCID: PMC10051142.

1. Stachelscheid J, Jiang Q, Aszyk C, Warner K, Bley N, Müller T, Vydzhak O, Symeonidis K, Crispatzu G, Mayer P, Blakemore SJ, Goehring G, Newrzela S, Hippler S, Robrecht S, Kreuzer KA, Pallasch C, Krüger M, Lechner A, Fischer K, Stilgenbauer S, Beutner D, Hallek M, Auguin D, Hüttelmaier S, Bloehdorn J, Vasyutina E, Herling M. The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL. Blood. 2023 Mar 23;141(12):1425-1441. doi.org/10.1182/blood.2022015494. PMID: 36179280.

2. Gialesaki S, Bräuer-Hartmann D, Issa H, Bhayadia R, Alejo-Valle O, Verboon L, Schmell AL, Laszig S, Regényi E, Schuschel K, Labuhn M, Ng M, Winkler R, Ihling C, Sinz A, Glaß M, Hüttelmaier S, Matzk S, Schmid L, Strüwe FJ, Kadel SK, Reinhardt D, Yaspo ML, Heckl D, Klusmann JH. RUNX1 isoform disequilibrium promotes the development of trisomy 21-associated myeloid leukemia. Blood. 2023 Mar 9;141(10):1105-1118. doi.org/10.1182/blood.2022017619. PMID: 36493345; PMCID: PMC10023736.

3. Mestre-Farràs N, Guerrero S, Bley N, Rivero E, Coll O, Borràs E, Sabidó E, Indacochea A, Casillas-Serra C, Järvelin AI, Oliva B, Castello A, Hüttelmaier S, Gebauer F. Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis. Nucleic Acids Res. 2022 Aug 12;50(14):8207-8225. doi.org/10.1093/nar/gkac605. PMID: 35848924; PMCID: PMC9371929.

4. Zinnall U, Milek M, Minia I, Vieira-Vieira CH, Müller S, Mastrobuoni G, Hazapis OG, Del Giudice S, Schwefel D, Bley N, Voigt F, Chao JA, Kempa S, Hüttelmaier S, Selbach M, Landthaler M. HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins. Nat Commun. 2022 May 18;13(1):2727. doi.org/10.1038/s41467-022-30322-7. PMID: 35585045; PMCID: PMC9117268.

5. Sperling F, Misiak D, Hüttelmaier S, Michl P, Griesmann H. IGF2BP1 Promotes Proliferation of Neuroendocrine Neoplasms by Post-Transcriptional Enhancement of EZH2. Cancers (Basel). 2022 Apr 24;14(9):2121. doi.org/10.3390/cancers14092121. PMID: 35565249.

6. Braun T, Stachelscheid J, Bley N, Oberbeck S, Otte M, Müller TA, Wahnschaffe L, Glaß M, Ommer K, Franitza M, Gathof B, Altmüller J, Hallek M, Auguin D, Hüttelmaier S, Schrader A, Herling M. Noncanonical Function of AGO2 Augments T-cell Receptor Signaling in T-cell Prolymphocytic Leukemia. Cancer Res. 2022 May 3;82(9):1818-1831. doi.org/10.1158/0008-5472.CAN-21-1908. PMID: 35259248.

1. Glaß M, Schian L, Misiak D, Misiak C, Müller S, Rausch A, Angermann K, Hoyer M, Zabel R, Battula R, Kehlen A, Möbius B, Weickert J, Hüttelmaier S, Karrasch M. It did not stop there: rapid substitution of circulating SARS-CoV-2 variant of concern B.1.1.7 (Alpha) by variant of concern B.1.617.2 (Delta) and further evolution of different Delta sublineages in Southern Saxony-Anhalt in late summer 2021. LaboratoriumsMedizin, vol. 46, no. 1, 2022, pp. 77-78. doi.org/10.1515/labmed-2021-0168.

2. Misiak D, Bauer M, Lange J, Haase J, Braun J, Lorenz K, Wickenhauser C, Hüttelmaier S. MiRNA Deregulation Distinguishes Anaplastic Thyroid Carcinoma (ATC) and Supports Upregulation of Oncogene Expression. Cancers (Basel). 2021 Nov 24;13(23):5913. doi.org/10.3390/cancers13235913. PMID: 34885022.

3. Glaß, Markus, Misiak, Danny, Misiak, Claudia, Müller, Simon, Rausch, Alexander, Angermann, Katharina, Hoyer, Mariann, Zabel, Ramona, Kehlen, Astrid, Möbius, Beate, Weickert, Jessica, Hüttelmaier, Stefan and Karrasch, Matthias. "Fast forward evolution in real time: the rapid spread of SARS-CoV-2 variant of concern lineage B.1.1.7 in Saxony-Anhalt over a period of 5 months". LaboratoriumsMedizin, vol. 46, no. 1, 2022, pp. 71-75. doi.org/10.1515/labmed-2021-0092.

4. Hupfeld J, Ernst M, Knyrim M, Binas S, Kloeckner U, Rabe S, Quarch K, Misiak D, Fuszard M, Grossmann C, Gekle M, Schreier B. miR-208b Reduces the Expression of Kcnj5 in a Cardiomyocyte Cell Line. Biomedicines. 2021 Jun 23;9(7):719. doi: 10.3390/biomedicines9070719. PMID: 34201741.

5. Weiße J, Rosemann J, Müller L, Kappler M, Eckert AW, Glaß M, Misiak D, Hüttelmaier S, Ballhausen WG, Hatzfeld M, Haemmerle M, Gutschner T. Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation. Mol Cancer. 2021 Jun 11;20(1):88. doi.org/10.1186/s12943-021-01384-w. PMID: 34116687.

6. Lederer M, Müller S, Glaß M, Bley N, Ihling C, Sinz A, Hüttelmaier S. Oncogenic Potential of the Dual-Function Protein MEX3A. Biology (Basel). 2021 May 7;10(5):415. doi.org/10.3390/biology10050415. PMID: 34067172.

7. Misiak D, Hagemann S, Bell JL, Busch B, Lederer M, Bley N, Schulte JH, Hüttelmaier S. The MicroRNA Landscape of MYCN-Amplified Neuroblastoma. Front Oncol. 2021 May 7;11:647737. doi.org/10.3389/fonc.2021.647737. PMID: 34026620.

8. Bley N, Hmedat A, Müller S, Rolnik R, Rausch A, Lederer M, Hüttelmaier S. Musashi-1-A Stemness RBP for Cancer Therapy? Biology (Basel). 2021 May 5;10(5):407. doi.org/10.3390/biology10050407. PMID: 34062997.

9. Glaß M, Misiak D, Bley N, Müller S, Hagemann S, Busch B, Rausch A, Hüttelmaier S. IGF2BP1, a Conserved Regulator of RNA Turnover in Cancer. Front Mol Biosci. 2021 Mar 22;8:632219. doi.org/10.3389/fmolb.2021.632219. PMID: 33829040.

10. Zorn P, Misiak D, Gekle M, Köhn M. Identification and initial characterization of POLIII-driven transcripts by msRNA-sequencing. RNA Biol. 2021 Nov;18(11):1807-1817. doi.org/10.1080/15476286.2020.1871216. Epub 2021 Jan 18. PMID: 33404286.

1. Braun T, Glass M, Wahnschaffe L, Otte M, Mayer P, Franitza M, Altmüller J, Hallek M, Hüttelmaier S, Schrader A, Herling M. Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways. Haematologica; doi.org/10.3324/haematol.2020.267500 [Early view].
2. Pötschke R, Haase J, Glaß M, Simmermacher S, Misiak C, Penalva LOF, Kühnöl CD, Hüttelmaier S. MSI1 Promotes the Expression of the GBM Stem Cell Marker CD44 by Impairing miRNA-Dependent Degradation. Cancers (Basel). 2020 Dec 5;12(12):E3654. doi.org/10.3390/cancers12123654. PMID: 33291443.
3. Cui C, Liu Y, Gerloff D, Rohde C, Pauli C, Köhn M, Misiak D, Oellerich T, Schwartz S, Schmidt LH, Wiewrodt R, Marra A, Hillejan L, Bartel F, Wickenhauser C, Hüttelmaier S, Göllner S, Zhou F, Edemir B, Müller-Tidow C. NOP10 predicts lung cancer prognosis and its associated small nucleolar RNAs drive proliferation and migration. Oncogene. 2020 Dec 7. https://doi.org/10.1038/s41388-020-01570-y. Epub ahead of print. PMID: 33288886.
4. Spielmann J, Mattheis L, Jung JS, Rauße H, Glaß M, Bähr I, Quandt D, Oswald J, Kielstein H. Effects of obesity on NK cells in a mouse model of postmenopausal breast cancer. Sci Rep. 2020 Nov 26;10(1):20606. doi.org/10.1038/s41598-020-76906-5. PMID: 33244094.
5. Gnoth K, Piechotta A, Kleinschmidt M, Konrath S, Schenk M, Taudte N, Ramsbeck D, Rieckmann V, Geissler S, Eichentopf R, Barendrecht S, Hartlage-Rübsamen M, Demuth HU, Roßner S, Cynis H, Rahfeld JU, Schilling S. Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology. Alzheimers Res Ther. 2020 Nov 14;12(1):149. doi.org/10.1186/s13195-020-00719-x. PMID: 33189132; PMCID: PMC7666770.
6. Martínez DG, Hüttelmaier S, Bertoldo JB. Unveiling Druggable Pockets by Site-Specific Protein Modification: Beyond Antibody-Drug Conjugates. Front Chem. 2020 Oct 21;8:586942. doi.org/10.3389/fchem.2020.586942. PMID: 33195086.
7. Stern C, Schreier B, Nolze A, Rabe S, Mildenberger S, Gekle M. Knockout of vascular smooth muscle EGF receptor in a mouse model prevents obesity-induced vascular dysfunction and renal damage in vivo. Diabetologia. 2020 Oct;63(10):2218-2234. doi.org/10.1007/s00125-020-05187-4. Epub 2020 Jun 17. PMID: 32548701; PMCID: PMC7476975.
8. Ho-Xuan H, Glažar P, Latini C, Heizler K, Haase J, Hett R, Anders M, Weichmann F, Bruckmann A, Van den Berg D, Hüttelmaier S, Rajewsky N, Hackl C, Meister G. Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts. Nucleic Acids Res. 2020 Sep 21:gkaa704. doi.org/10.1093/nar/gkaa704. Epub ahead of print. PMID: 32955563.
9. Holstein I, Singh AK, Pohl F, Misiak D, Braun J, Leitner L, Hüttelmaier S, Posern G. Post-transcriptional regulation of MRTF-A by miRNAs during myogenic differentiation of myoblasts. Nucleic Acids Res. 2020 Sep 18;48(16):8927-8942. doi.org/10.1093/nar/gkaa596. PMID: 32692361.
10. Bähr I, Pörtner OJ, Glass M, Doberstein H, Goritz V, Hiller GGR, Spielmann J, Kielstein H. Characterization of natural killer cells in colorectal tumor tissue of rats fed a control diet or a high-fat diet. Ann Anat. 2020 Sep 9:151586. doi.org/10.1016/j.aanat.2020.151586. Epub ahead of print. PMID: 32916268.
11. Müller S, Bley N, Busch B, Glaß M, Lederer M, Misiak C, Fuchs T, Wedler A, Haase J, Bertoldo JB, Michl P, Hüttelmaier S. The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer. Nucleic Acids Res. 2020 Sep 4;48(15):8576-8590. doi.org/10.1093/nar/gkaa653. PMID: 32761127.
12. Bley N, Schott A, Müller S, Misiak D, Lederer M, Fuchs T, Aßmann C, Glaß M, Ihling C, Sinz A, Pazaitis N, Wickenhauser C, Vetter M, Ungurs O, Strauss HG, Thomssen C, Hüttelmaier S. IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer. RNA Biol. 2020 Sep 2:1-13. doi.org/10.1080/15476286.2020.1812894. Epub ahead of print. PMID: 32876513.
13. Liu H, Ding J, Köhnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz LO, Hollemann T, Pfirrmann T. The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan. Autophagy. 2020 Sep;16(9):1618-1634. doi.org/10.1080/15548627.2019.1695399. Epub 2019 Dec 3. PMID: 31795790.
14. Simon Müller, Alice Wedler, Janina Breuer, Markus Glaß, Nadine Bley, Marcell Lederer, Jacob Haase, Claudia Misiak, Tommy Fuchs, Alina Ottmann, Tessa Schmachtel, Lyudmila Shalamova, Alexander Ewe, Achim Aigner, Oliver Rossbach, Stefan Hüttelmaier, Synthetic circular miR-21 RNA decoys enhance tumor suppressor expression and impair tumor growth in mice, NAR Cancer, Volume 2, Issue 3, 1 September 2020, zcaa014, doi.org/10.1093/narcan/zcaa014
15. Haase J, Misiak D, Bauer M, Pazaitis N, Braun J, Pötschke R, Mensch A, Bell JL, Dralle H, Siebolts U, Wickenhauser C, Lorenz K, Hüttelmaier S. IGF2BP1 is the first positive marker for anaplastic thyroid carcinoma diagnosis. Mod Pathol. 2020 Jul 27. doi.org/10.1038/s41379-020-0630-0. Epub ahead of print. PMID: 32719445.
16. Glaß M, Dorn A, Hüttelmaier S, Haemmerle M, Gutschner T. Comprehensive Analysis of LincRNAs in Classical and Basal-Like Subtypes of Pancreatic Cancer. Cancers (Basel). 2020 Jul 27;12(8):E2077. doi.org/10.3390/cancers12082077. PMID: 32727085.
17. Bell JL, Hagemann S, Holien JK, Liu T, Nagy Z, Schulte JH, Misiak D, Hüttelmaier S. Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma. Int J Mol Sci. 2020 Jul 19;21(14):E5098. doi.org/10.3390/ijms21145098. PMID: 32707690.
18. Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert FD, Angstman NB, Cardoso MC, König J, Hüttelmaier S, Dieterich C, Canzar S, Helm M, Heissmeyer V, Feederle R, Meister G. Validation strategies for antibodies targeting modified ribonucleotides. RNA. 2020 Oct;26(10):1489-1506. doi.org/10.1261/rna.076026.120. Epub 2020 Jul 7. PMID: 32636310.
19. Ihling C, Tänzler D, Hagemann S, Kehlen A, Hüttelmaier S, Arlt C, Sinz A. Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of COVID-19 Patients. J Proteome Res. 2020 Jun 23. doi.org/10.1021/acs.jproteome.0c00280. Epub ahead of print. PMID: 32568543.
20. Hohmann T, Hohmann U, Kolbe MR, Dahlmann M, Kobelt D, Stein U, Dehghani F. MACC1 driven alterations in cellular biomechanics facilitate cell motility in glioblastoma. Cell Commun Signal. 2020 Jun 5;18(1):85. doi.org/10.1186/s12964-020-00566-1. PMID: 32503676; PMCID: PMC7275321.
21. Glaß M, Michl P, Hüttelmaier S. RNA Binding Proteins as Drivers and Therapeutic Target Candidates in Pancreatic Ductal Adenocarcinoma. Int J Mol Sci. 2020 Jun 11;21(11):E4190. doi.org/10.3390/ijms21114190. PMID: 32545414.
22. Bley N. Finding the mutations that drive resistance. Elife. 2020 May 15;9:e57678. doi.org/10.7554/eLife.57678. PMID: 32408944; PMCID: PMC7228763.
23. Dorn A, Glaß M, Neu CT, Heydel B, Hüttelmaier S, Gutschner T, Haemmerle M. LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity. Cancers (Basel). 2020 May 13;12(5):E1227. doi.org/10.3390/cancers12051227. PMID: 32414223.
24. Schuschel K, Helwig M, Hüttelmaier S, Heckl D, Klusmann JH, Hoell JI. RNA-Binding Proteins in Acute Leukemias. Int J Mol Sci. 2020 May 12;21(10):E3409. doi.org/10.3390/ijms21103409. PMID: 32408494.
25. Zibolka J, Wolf A, Rieger L, Rothgänger C, Jörns A, Lutz B, Zimmer A, Dehghani F, Bazwinsky-Wutschke I. Influence of Cannabinoid Receptor Deficiency on Parameters Involved in Blood Glucose Regulation in Mice. Int J Mol Sci. 2020 Apr 30;21(9):3168. doi.org/10.3390/ijms21093168. PMID: 32365865; PMCID: PMC7246639.
26. von Spreckelsen N, Waldt N, Poetschke R, Kesseler C, Dohmen H, Jiao HK, Nemeth A, Schob S, Scherlach C, Sandalcioglu IE, Deckert M, Angenstein F, Krischek B, Stavrinou P, Timmer M, Remke M, Kirches E, Goldbrunner R, Chiocca EA, Huettelmaier S, Acker T, Mawrin C. KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment. Acta Neuropathol Commun. 2020 Apr 3;8(1):41. doi.org/10.1186/s40478-020-00912-x. PMID: 32245394; PMCID: PMC7118946.
27. Müller L, Rietscher K, Keil R, Neuholz M, Hatzfeld M. Plakophilin 3 phosphorylation by ribosomal S6 kinases supports desmosome assembly. J Cell Sci. 2020 Apr 16;133(8):jcs238295. doi.org/10.1242/jcs.238295. PMID: 32122945.
28. Groß A, Chernyakov D, Gallwitz L, Bornkessel N, Edemir B. Deletion of Von Hippel-Lindau Interferes with Hyper Osmolality Induced Gene Expression and Induces an Unfavorable Gene Expression Pattern. Cancers (Basel). 2020 Feb 12;12(2):420. doi.org/10.3390/cancers12020420. PMID: 32059438; PMCID: PMC7073186.

1. Wach S, Taubert H, Weigelt K, Hase N, Köhn M, Misiak D, Hüttelmaier S, Stöhr CG, Kahlmeyer A, Haller F, Vera J, Hartmann A, Wullich B, Lai X. RNA Sequencing of Collecting Duct Renal Cell Carcinoma Suggests an Interaction between miRNA and Target Genes and a Predominance of Deregulated Solute Carrier Genes. Cancers (Basel). 2019 Dec 24;12(1). pii: E64. doi.org/10.3390/cancers12010064. PubMed PMID: 31878355.
2. Pötschke R, Gielen G, Pietsch T, Kramm C, Klusmann JH, Hüttelmaier S, Kühnöl CD. Musashi1 enhances chemotherapy resistance of pediatric glioblastoma cells in vitro. Pediatr Res. 2020 Mar;87(4):669-676. doi.org/10.1038/s41390-019-0628-9. Epub 2019 Nov 22. PMID: 31756732.
3. Fu H, Alabdullah M, Großmann J, Spieler F, Abdosh R, Lutz V, Kalies K, Knöpp K, Rieckmann M, Koch S, Noutsias M, Pilowski C, Dutzmann J, Sedding D, Hüttelmaier S, Umezawa K, Werdan K, Loppnow H. The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation. Cell Death Dis. 2019 Nov 21;10(12):880. doi.org/10.1038/s41419-019-2109-9. PubMed PMID: 31754207; PubMed Central PMCID: PMC6872739.
4. Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM. Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface. Cancer Res. 2019 Nov 1;79(21):5652-5667. doi.org/10.1158/0008-5472.CAN-19-1112. Epub 2019 Sep 9. PubMed PMID: 31501192.
5. Binas S, Knyrim M, Hupfeld J, Kloeckner U, Rabe S, Mildenberger S, Quarch K, Strätz N, Misiak D, Gekle M, Grossmann C, Schreier B. miR-221 and -222 target CACNA1C and KCNJ5 leading to altered cardiac ion channel expression and current density. Cell Mol Life Sci. 2019 Jul 16. doi.org/10.1007/s00018-019-03217-y. [Epub ahead of print] PubMed PMID: 31312877.
6. Weiss-Sadan T, Maimoun D, Oelschlagel D, Kaschani F, Misiak D, Gaikwad H, Ben-Nun Y, Merquiol E, Anaki A, Tsvirkun D, Kaiser M, Michl P, Gotsman I, Blum G. Cathepsins Drive Anti-Inflammatory Activity by Regulating Autophagy and Mitochondrial Dynamics in Macrophage Foam Cells. Cell Physiol Biochem. 2019;53(3):550-572. doi.org/10.33594/000000157. PubMed PMID: 31529928.
7. Lindstedt PR, Aprile FA, Matos MJ, Perni M, Bertoldo JB, Bernardim B, Peter Q, Jiménez-Osés G, Knowles TPJ, Dobson CM, Corzana F, Vendruscolo M, Bernardes GJL. Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification. ACS Cent Sci. 2019 Aug 28;5(8):1417-1424. doi.org/10.1021/acscentsci.9b00467. Epub 2019 Jul 19. PubMed PMID: 31482124; PubMed Central PMCID: PMC6716132.
8. Wong M, Sun Y, Xi Z, Milazzo G, Poulos RC, Bartenhagen C, Bell JL, Mayoh C, Ho N, Tee AE, Chen X, Li Y, Ciaccio R, Liu PY, Jiang CC, Lan Q, Jayatilleke N, Cheung BB, Haber M, Norris MD, Zhang XD, Marshall GM, Wang JY, Hüttelmaier S, Fischer M, Wong JWH, Xu H, Perini G, Dong Q, George RE, Liu T. JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma. Nat Commun. 2019 Jul 25;10(1):3319. doi.org/10.1038/s41467-019-11132-w. PubMed PMID: 31346162.
9. Kessler J, Hohmann T, Güttler A, Petrenko M, Ostheimer C, Hohmann U, Bache M, Dehghani F, Vordermark D. Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the Mechanisms. Cancers (Basel). 2019 Jun 25;11(6):889. doi.org/10.3390/cancers11060889. PMID: 31242696; PMCID: PMC6627228.
10. Täuber H, Hüttelmaier S, Köhn M. POLIII-derived non-coding RNAs acting as scaffolds and decoys. J Mol Cell Biol. 2019 Jun 1. pii: mjz049. doi.org/10.1093/jmcb/mjz049. [Epub ahead of print] PubMed PMID: 31152666.
11. Schneider T, Hung LH, Aziz M, Wilmen A, Thaum S, Wagner J, Janowski R, Müller S, Schreiner S, Friedhoff P, Hüttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A. Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3. Nat Commun. 2019 May 22;10(1):2266. doi.org/10.1038/s41467-019-09769-8. PubMed PMID: 31118463; PubMed Central PMCID: PMC6531468.
12. Lan Q, Liu PY, Haase J, Bell JL, Hüttelmaier S, Liu T. The Critical Role of RNA m(6)A Methylation in Cancer. Cancer Res. 2019 Apr 1;79(7):1285-1292. doi.org/10.1158/0008-5472.CAN-18-2965. Epub 2019 Mar 20. Review. PubMed PMID: 30894375.
13. Grabiec U, Hohmann T, Ghadban C, Rothgänger C, Wong D, Antonietti A, Groth T, Mackie K, Dehghani F. Protective Effect of N-Arachidonoyl Glycine-GPR18 Signaling after Excitotoxical Lesion in Murine Organotypic Hippocampal Slice Cultures. Int J Mol Sci. 2019 Mar 13;20(6):1266. doi.org/10.3390/ijms20061266. PMID: 30871175; PMCID: PMC6470786.

2018

Müller S, Glaß M, Singh AK, Haase J, Bley N, Fuchs T, Lederer M, Dahl A, Huang H, Chen J, Posern G, Hüttelmaier S. IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner. Nucleic Acids Res. 2019 Jan 10;47(1):375-390. doi: 10.1093/nar/gky1012. PMID: 30371874; PMCID: PMC6326824.

Mensch A, Meinhardt B, Bley N, Hüttelmaier S, Schneider I, Stoltenburg-Didinger G, Kraya T, Müller T, Zierz S. The p.S85C-mutation in MATR3 impairs stress granule formation in Matrin-3 myopathy. Exp Neurol. 2018 Aug;306:222-231.

Zibolka J, Bazwinsky-Wutschke I, Mühlbauer E, Peschke E. Distribution and density of melatonin receptors in human main pancreatic islet cell types. J Pineal Res. 2018 Aug;65(1):e12480. doi.org/10.1111/jpi.12480. Epub 2018 Mar 25. PMID: 29464840.

Tebaldi T, Zuccotti P, Peroni D, Köhn M, Gasperini L, Potrich V, Bonazza V, Dudnakova T, Rossi A, Sanguinetti G, Conti L, Macchi P, D'Agostino V, Viero G, Tollervey D, Hüttelmaier S, Quattrone A. HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA. Mol Cell. 2018 Jul 19;71(2):256-270.e10. doi: 10.1016/j.molcel.2018.06.032. PMID: 30029004; PMCID: PMC6060611.

Müller S, Bley N, Glaß M, Busch B, Rousseau V, Misiak D, Fuchs T, Lederer M, Hüttelmaier S. IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors. Nucleic Acids Res. 2018 Jul 6;46(12):6285-6303.

Rietscher K, Keil R, Jordan A, Hatzfeld M. 14-3-3 proteins regulate desmosomal adhesion via plakophilins. J Cell Sci. 2018 May 22;131(10):jcs212191. doi.org/10.1242/jcs.212191. PMID: 29678907.

2017

Schneider M, Prudic K, Pippel A, Klapperstück M, Braam U, Müller CE, Schmalzing G, Markwardt F. Interaction of Purinergic P2X4 and P2X7 Receptor Subunits. Front Pharmacol. 2017 Nov 22;8:860.

Becher A, Eiseler T, Porzner M, Walther P, Keil R, Bobrovich S, Hatzfeld M, Seufferlein T. The armadillo protein p0071 controls KIF3 motor transport. J Cell Sci. 2017 Oct 1;130(19):3374-3387. doi.org/10.1242/jcs.200170. Epub 2017 Aug 14. PMID: 28808088.

Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, Misiak D, Bäumer N, Cui C, Göllner S, Oellerich T, Serve H, Garcia-Cuellar MP, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein HU, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hébert J, Sauvageau G, Pabst C, Hüttelmaier S, Müller-Tidow C. AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia. Nat Cell Biol. 2017 Jul;19(7):844-855. doi.org/10.1038/ncb3563. Epub 2017 Jun 26. PMID: 28650479.

Veß A, Blache U, Leitner L, Kurz ARM, Ehrenpfordt A, Sixt M, Posern G. A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. J Cell Sci. 2017 Jul 1;130(13):2172-2184. doi.org/10.1242/jcs.200899. Epub 2017 May 17. PMID: 28515231.

Seifert A, Posern G. Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini. Breast Cancer Res. 2017 Jun 7;19(1):68. doi.org/10.1186/s13058-017-0860-3. PMID: 28592291; PMCID: PMC5463372.

2016

Wurth L, Papasaikas P, Olmeda D, Bley N, Calvo GT, Guerrero S, Cerezo-Wallis D, Martinez-Useros J, García-Fernández M, Hüttelmaier S, Soengas MS, Gebauer F. UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis. Cancer Cell. 2016 Nov 14;30(5):694-707.

Möller B, Glaß M, Misiak D, Posch S. MiToBo - A Toolbox for Image Processing and Analysis. Journal of Open Research Software. 2016;4(1):e17.

Keil R, Rietscher K, Hatzfeld M. Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3. J Invest Dermatol. 2016 Oct;136(10):2022-9.

Theil G, Fischer K, Weber E, Medek R, Hoda R, Lücke K, Fornara P. The Use of a New CellCollector to Isolate Circulating Tumor Cells from the Blood of Patients with Different Stages of Prostate Cancer and Clinical Outcomes - A Proof-of-Concept Study. PLoS One. 2016 Aug 1;11(8):e0158354. doi.org/10.1371/journal.pone.0158354. PMID: 27479125; PMCID: PMC4968821.

Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M. Growth retardation, loss of desmosomal adhesion and impaired tight junction function identify a unique role of plakophilin 1 in vivo. J Invest Dermatol. 2016 Mar 28. pii: S0022-202X(16)30984-8.

Busch B, Bley N, Müller S, Glaß M, Misiak D, Lederer M, Vetter M, Strauß HG, Thomssen C, Hüttelmaier S. The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Res. 2016 May 5;44(8):3845-64.

Bretschneider M, Busch B, Mueller D, Nolze A, Schreier B, Gekle M, Grossmann C. Activated mineralocorticoid receptor regulates micro-RNA-29b in vascular smooth muscle cells. FASEB J. 2016 Jan 4. pii: fj.15-271254.

2015

Köhn M, Ihling C, Sinz A, Krohn K, Hüttelmaier S. The Y3** ncRNA promotes the 3' end processing of histone mRNAs. Genes Dev. 2015 Oct 1;29(19):1998-2003.

Bell JL, Turlapati R, Liu T, Schulte JH, Hüttelmaier S. IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma. J Clin Oncol. 2015 Apr 10;33(11):1285-93.

Bley N, Lederer M, Pfalz B, Reinke C, Fuchs T, Glaß M, Möller B, Hüttelmaier S. Stress granules are dispensable for mRNA stabilization during cellular stress. Nucleic Acids Res. 2015 Feb 27;43(4):e26.

2014

Keil R, Hatzfeld M. The armadillo protein p0071 is involved in Rab11-dependent recycling. J Cell Sci. 2014 Jan 1;127(Pt 1):60-71.

Lederer M, Bley N, Schleifer C, Hüttelmaier S. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. Semin Cancer Biol. 2014 Dec; 29:3-12.  

Riemann A, Schneider B, Gündel D, Stock C, Thews O, Gekle M. Acidic priming enhances metastatic potential of cancer cells. Pflügers Archiv: DOI 10.1007/s00424-014-1458-6 (2014)

Möller B, Piltz E, Bley N. Quantification of Actin Structures using Unsupervised Pattern Analysis Techniques. Proceedings International Conference on Pattern Recognition (ICPR), IEEE, pp. to appear, Stockholm, Sweden, August 2014.

Misiak D, Posch S, Lederer M, Reinke C, Hüttelmaier S, Möller B. Extraction of protein profiles from primary neurons using active contour models and wavelets. Journal of Neuroscience Methods, Volume 225, 30 March 2014, Pages 1-12. pii: S0165-0270(13)00433-0.

Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Groß M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S. The Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important pro-tumorigenic factor in hepatocellular carcinoma. Hepatology. 2014 Jan 7.

2013

Nolze A, Schneider J, Keil R, Lederer M, Hüttelmaier S, Kessels MM, Qualmann B, Hatzfeld M. FMRP regulates actin filament organization via the armadillo protein p0071. RNA. 2013 Nov;19(11):1483-96. doi.org/10.1261/rna.037945.112. Epub 2013 Sep 23. PMID: 24062571; PMCID: PMC3851716.

Zirkel A, Lederer M, Stöhr N, Pazaitis N, Hüttelmaier S. IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). Nucleic Acids Res. 2013 May 15.

Wächter K, Köhn M, Stöhr N, Hüttelmaier S. Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA binding proteins) is modulated by distinct RNA-binding domains. Biol Chem. 2013 May 1. doi:10.1515/hsz-2013-0111.

Wolf A, Rietscher K, Glaß M, Hüttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M (2013). Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation. J Cell Sci 126: 1832-1844.7

Köhn M, Pazaitis  N, Hüttelmaier, S. Why YRNAs? About Versatile RNAs and Their Functions. Biomolecules 2013, 3(1), 143-156. 2013 Feb 13.

2012

Glaß M, Möller B, Zirkel A, Wächter K, Hüttelmaier S, Posch S. Cell migration analysis: Segmenting scratch assay images with level sets and support vector machines. Pattern Recognition, Volume 45, Issue 9, September 2012, Pages 3154-3165, ISSN 0031-3203, 10.1016/j.patcog.2012.03.00.

Seltmann K, Roth W, Kröger C, Loschke F, Lederer M, Hüttelmaier S, Magin TM. Keratins mediate localization of hemidesmosomes and repress cell motility. J Invest Dermatol. 2013 Jan;133(1):181-90.

Stöhr N, Hüttelmaier S. IGF2BP1: a post-transcriptional "driver" of tumor cell migration. Cell Adh Migr. 2012 Jul-Aug;6(4):312-8.

Eiseler T, Koehler C, Nimmagadda SC, Jamali A, Funk N, Joodi G, Storz P, Seufferlein T. Protein Kinase D1 mediates anchorage-dependent and independent growth of tumor cells via the zinc-finger transcription factor Snail1. J Biol Chem. 2012 Jul 12.

Ruhs S, Strätz N, Schlör K, Meinel S, Mildenberger S, Rabe S, Gekle M, Grossmann C. Modulation of transcriptional mineralocorticoid receptor activity by nitrosative stress. Free Radic Biol Med. 2012 Jun 26;53(5):1088-1100.

Grossmann C, Ruhs, S, Langenbruch, L, Mildenberger, S, Straetz, N, Schumann, K, Gekle, M. Nuclear Shuttling Precedes Dimerization in Mineralocorticoid Receptor Signaling. Chem Biol. 2012 Jun 22;19(6):742-51.

Seiferth A, Ruhs S, Mildenberger S, Gekle M, Grossmann C. The phosphatase calcineurin PP2BAβ mediates part of mineralocorticoid receptor transcriptional activity. FASEB J. 2012 Jun;26(6):2327-37.

Berndt H, Harnisch C, Rammelt C, Stöhr N, Zirkel A, Dohm JC, Himmelbauer H,Tavanez JP, Hüttelmaier S, Wahle E. Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. RNA. 2012 May;18(5):958-72.

Busch T, Armacki M, Eiseler T, Joodi G, Temme C, Jansen J, von Wichert G, Omary MB, Spatz J, Seufferlein T. Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. J Cell Sci. 2012 May 1;125(Pt 9):2148-59.

Stöhr N, Köhn M, Lederer M, Glaß M, Reinke C, Singer RH, Hüttelmaier S. IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev. 2012 Jan 15;26(2):176-189.

2011

Fronz K, Güttinger S, Burkert K, Kühn U, Stöhr N, Schierhorn A, Wahle E. Arginine methylation of the nuclear poly(A) binding protein weakens the interaction with its nuclear import receptor, transportin. J Biol Chem. 2011 Aug 1.

Braun J, Hüttelmaier S. Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular origin. Thyroid Research. 2011 August 3; vol. 4.

Glaß M, Möller B, Zirkel A, Wächter K, Hüttelmaier S, Posch S. Scratch assay analysis with topology-preserving level sets and texture measures. Proc. of 5th Iberian Conference on Pattern Recognition and Image Analysis (IbPRIA '11), pages 100-108, Gran Canaria, Spain, 2011

2010

Möller B, Stöhr N, Hüttelmaier S, Posch S. Cascaded Segmentation of Grained Cell Tissue with Active Contour Models. In Proc. of Int. Conf. on Pattern Recognition (ICPR), IEEE, pp. 1481-1484, Istanbul, Turkey, August 2010.

Grossmann C, Husse B, Mildenberger S, Schreier B, Schuman K, Gekle M. Colocalization of mineralocorticoid and EGF receptor at the plasma membrane. Biochim Biophys Acta. 2010 May;1803(5):584-90.

Braun J, Hoang-Vu C, Dralle H, Hüttelmaier S. Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. Oncogene. 2010 May 24.

Köhn M, Lederer M, Wächter K, Hüttelmaier S. Near-infrared (NIR) dye-labeled RNAs identify binding of ZBP1 to the noncoding Y3-RNA. RNA. 2010 Jul;16(7):1420-8.

Möller B, Greß O, Stöhr N, Hüttelmaier S, Posch S. Adaptive segmentation of cells and particles in fluorescent microscope images. In Proc. of International Conference on Computer Vision Theory and Applications (VISAPP '10), vol. 2, pp. 97-106, Angers, France, May 2010.

Wolf A, Krause-Gruszczynska M, Birkenmeier O, Ostareck-Lederer A, Hüttelmaier S, Hatzfeld M. Plakophilin 1 stimulates translation by promoting eIF4A1 activity.J Cell Biol. 2010 Feb 22;188(4):463-71.