- Seit 11/2023:
Stellvertretender Vorstand der AG ”Statistische Methodik in der klinischen Forschung“ der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS) e.V. - Seit 03/2021:
Wissenschaftliche Mitarbeiterin, Institut für Medizinische Epidemiologie, Biometrie und Informatik, Martin-Luther-Universität Halle-Wittenberg - 2016-2021:
Erstes Staatsexamen für Lehramt an Gymnasien für die Fächer Mathematik & Biologie, Martin-Luther-Universität Halle-Wittenberg - 2017-2020:
Bachelor of Science, Martin-Luther-Universität Halle-Wittenberg
- Thema:
Uncovering hidden influence in survival analysis: Impact of omitted covariates on treatment estimates in randomized and propensity score matched studies
- Beschreibung:
Hazard Ratios (HRs) are the most common treatment effect measure in clinical trials focusing on time-to-event outcomes. However, recent years have witnessed an increasing critique of HRs, particularly regarding their non-collapsibility or with respect to their causal interpretation. This work addresses another critical aspect related to omitted covariates that may impact the survival outcome and/or the treatment allocation but are frequently disregarded. We present a methodological approach called Dynamic Landmarking, providing a visual indication of potentially biased treatment effect estimates and identifying omitted covariates that could induce this bias. Furthermore, we use the method to assess the bias in individual patient data from 27 large randomized controlled trials (RCTs) in order to examine the practical relevance of omitted covariates in a randomized setting.
Ausgewählte Publikationen
- Strobel A, Wienke A, Kuss O. How hazardous are hazard ratios? An empirical investigation of individual patient data from 27 large randomized clinical trials. Eur J Epidemiol 2023 Aug; 38(8):859-867
- Kuss O, Strobel A. Gütemaße und Kriterien bei der Anwendung von Propensity Scores. GMS Med Inform Biom Epidemiol. 2024 Jan; 20:Doc01.
- Schultheis M, Grabbe S, Staubach P, Hennig K, Mauch M, Burckhardt M, Langer G, Heise M, Zamsheva M, Strobel A: Drivers of disease severity and burden of Hidradenitis suppurativa: - A cross-sectional analysis on 553 German patients Int. J. Dermatol. 2023 Nov; Advance online publication.
- Heise M, Staubach P, Nikolakis G, Schollenberger L, Mauch M, Burckhardt M, Zamsheva M, Strobel A, Langer G, Bechara F, Kirschner U, Hennig K, Kunte C, Goebeler M, Podda M, Grabbe S, Schultheis M. A center-based, ambulatory care concept for hidradenitis suppurativa improves patient outcomes and is also cost-effectiveness. J Dermatolog Treat. 2023 Dec;34(1):2284105.
