Publikationen

Bukhari S, Lerrer S, Straube J, Winchester R, Henick B, Dragovich M, Mor A. (2024) PD1 signaling uncovers a pathogenic subset of cytotoxic T cells. Cancer Res. 84 (6_Supplement): 1367. doi: 10.1158/1538-7445.AM2024-1367

Ernert C, Kielstein H, Azatyan A, Prantl L, Kehrer A. (2024) Extended arc of rotation of Latissimus Dorsi Musculocutaneous Flap providing well-vascularized tissue for reconstruction of complete defects of the sternum: An anatomical study of flap pedicle modification. Clin Hemorheol Microcirc. 86(1-2):225-236, doi: 10.3233/CH-238115

Griesler B, Hölzel M, Oswald J, Fänder J, Fischer T, Büttner M, Quandt D, Bähr I, Jasinski-Bergner S, Bazwinsky-Wutschke I, Kielstein H. (2024) Impact of siRNA-Mediated Cofilin-1 Knockdown and Obesity Associated Microenvironment on the Motility of Natural Killer Cells. Immunol Invest. doi: 10.1080/08820139.2024.2327327. Online ahead of print.

Hao LY, Lerrer S, Paiola M, Moore EK, Gartshteyn Y, Song R, Goeckeritz M, Black MJ, Bukhari S, Hu X, Mor A. (2024) Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function. Mol Ther Oncol. 32(3):200839. doi: 10.1016/j.omton.2024.200839

Straube J*, Bukhari S*, Lerrer S, Winchester RJ, Gartshteyn Y, Henick BS, Dragovich MA, Mor A. (2024) PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis. Arthritis Res Ther. 26(1):32. doi: 10.1186/s13075-023-03259-5 *These authors contributed equally to this work.

Utomo R, McWatt SC, Talis A, Xiao QY, Saraci K, Waschke J, Sigmund AM, Gill Sagoo M, Wingate R, Brassett C, Chien CL, Traxler H, Sakurai T, Zeroual M, Olsen J, El-Batti S, Viranta-Kovanen S, Yamada Y, Keay KA, Kitahara S, Stewart W, Mao Y, Lang A, Kunzel C, Bernd P, Patel S, Buehler L, Kielstein H, Preker A, Hardy MA, Noël GPJC, Wu A. (2024) Health profession students' outlooks on the medical profession during the COVID-19 pandemic: a global perspective. J Commun Healthc. 17(2):154-168. doi: 10.1080/17538068.2023.2214391

Wolff S, Adler S, Eppler E, Fischer K, Lux A, Rothkötter HJ, Skalej M (2024) Correlation of CT-based bone mineralization with drilling-force measurements in anatomical specimens is suitable to investigate planning of trans-pedicular spine interventions. Sci Rep. 14(1):1579. doi: 10.1038/s41598-023-50204-2

Balalian AA, Graeve R, Richter M, Fink A, Kielstein H, Martins SS, Philbin MM, Factor-Litvak P. (2023) Prenatal exposure to opioids and neurodevelopment in infancy and childhood: A systematic review. Front Pediatr. 11:1071889. doi: 10.3389/fped.2023.1071889

Kohler FC, Schenk P, Nies T, Hallbauer J, Hofmann GO, Biedermann U, Kielstein H, Wildemann B, Ramm R, Ullrich BW. (2023) Fibula Nail versus Locking Plate Fixation-A Biomechanical Study. J Clin Med. 12(2):698. doi: 10.3390/jcm12020698

Schilde S, Arbab D, Felsberg M, Kielstein H, Delank KS, Gutteck N. (2023) Open vs Minimally Invasive Resection of the First Metatarsocuneiform Joint: An Anatomical Study. Foot Ankle Int. 44(12)1287-1294. doi: 10.1177/10711007231200022

Wu A, McWatt S, Utomo R, Talis A, Xiao QY, Saraci K, Brassett C, Sagoo MG, Wingate R, Chien CL, Traxler H, Waschke J, Vielmuth F, Sigmund A, Yamada Y, Sakurai T, Zeroual M, Olsen J, El-Batti S, Viranta-Kovanen S, Keay K, Stewart W, Mao Y, Lang A, Kunzel C, Bernd P, Kielstein H, Noël GPJC. (2023) A thematic analysis of students' discussions on death and body donation in international online focus groups. Anat Sci Educ. 16(4):768-784. doi: 10.1002/ase.2265

Allweyer M, Emde M, Bähr I, Spielmann J, Bieramperl P, Naujoks W, Kielstein H. (2022) Investigation of Behavior and Plasma Levels of Corticosterone in Restrictive- and Ad Libitum-Fed Diet-Induced Obese Mice. Nutrients. 14(9):1746. doi: 10.3390/nu14091746

Bähr I, Jaeschke L, Nimptsch K, Janke J, Herrmann P, Kobelt D, Kielstein H, Pischon T*, Stein U*. (2022) Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association. Int J Oncol. 60(2):17. doi: 10.3892/ijo.2022.5307. *These authors contributed equally to this work.

Graeve R*, Balalian AA*, Richter M, Kielstein H, Fink A, Martins SS, Philbin MM, Factor-Litvak P. (2022) Infants' prenatal exposure to opioids and the association with birth outcomes: A systematic review and meta-analysis. Paediatr Perinat Epidemiol. 36(1):125-143. doi: 10.1111/ppe.12805. *These authors have contributed equally to this study.

Kosenko O, Steinicke C, Kielstein H, Steger F. (2022) Fetal Development in Anatomical Preparations of Ruysch and the Meckels in Comparison. Int. J. Environ. Res. Public Health. 19:14896. doi: 10.3390/ijerph192214896

Lehner E, Menzel M, Gündel D, Plontke SK, Mäder K, Klehm J, Kielstein H, Liebau A. (2022) Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear. Drug Deliv Transl Res. 12(1):257-266. doi:10.1007/s13346-021-00914-9

Wenzel CM, Meyer TM, Stoevesandt D, Kielstein H*, Kielstein JT*. (2022) Evaluation of the ideal length of the Seldinger needle for internal jugular vein catheter placement. Sci Rep. 12(1):2745. doi: 10.1038/s41598-022-06287-4. *These authors contributed equally to this work.

Wu A, Xiao QY, McWatt S, Utomo R, Talis A, Saraci K, Brassett C, Sagoo MG, Wingate R, Chien CL, Traxler H, Waschke J, Vielmuth F, Yamada Y, Sakurai T, Zeroual M, Olsen J, El-Batti S, Viranta-Kovanen S, Keay K, Stewart W, Kunzel C, Bernd P, Kielstein H, Noël GPJC (2022) The Anatomy Course During COVID-19: The Impact of Cadaver-Based Learning on the Initiation of Reflection on Death. Med Sci Educ. 32(5):1033-1044. doi: 10.1007/s40670-022-01609-7.

Zibolka J, Bähr I, Peschke E, Mühlbauer E, Bazwinsky-Wutschke I (2022) Human and Rodent Cell Lines as Models of Functional Melatonin-Responsive Pancreatic Islet Cells. In: Jockers, R., Cecon, E. (eds) Melatonin. Methods in Molecular Biology, vol 2550. Humana, New York, NY. doi: 10.1007/978-1-0716-2593-4_35

Link K, Shved N, Serrano N, Akgül G, Caelers A, Faass O, Mouttet F, Raabe O, D’Cotta H, Baroiller J-F and Eppler E (2022) Effects of seawater and freshwater challenges on the Gh/Igf system in the saline-tolerant blackchin tilapia (Sarotherodon melanotheron). Front. Endocrinol. 13:976488. doi: 10.3389/fendo.2022.976488

Bähr I, Pörtner OJ, Glass M, Doberstein H, Goritz V, Hiller GGR, Spielmann J, Kielstein H. (2021) Characterization of natural killer cells in colorectal tumor tissue of rats fed a control diet or a high-fat diet. Ann Anat. 233:151586. doi: 10.1016/j.aanat.2020.151586

Büttner M, Lagerholm CB, Waithe D, Galiani S, Schliebs W, Erdmann R, Eggeling C, Reglinski K. (2021) Challenges of Using Expansion Microscopy for Super-resolved Imaging of Cellular Organelles. Chembiochem. 22(4):686-693. doi:10.1002/cbic.202000571

Gutteck N, Ulbricht M, Delank KS, Kielstein H, Schilde S. (2021) Minimally invasive hallux valgus correction with Internal Hallux Fixator® - A comparative cadaver study. Foot Ankle Surg. doi: 10.1016/j.fas.2021.05.002. Online ahead of print.

Lautenbach A, Stoll F, Mann O, Busch P, Huber TB, Kielstein H, Bähr I, Aberle J. (2021) Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery. Obes Surg. 31(7):2913-2920. doi:10.1007/s11695-021-05315-y.

Scheer M, Griesler B, Ottlik E, Strauss C, Mawrin C, Kunze C, Prell J, Rampp S, Simmermacher S, Illert J, Kielstein H, Scheller C. (2021) Variability in the distance from the end of the gray matter to the end of the conus medullaris: a case-triggered histological investigation. J Neurosurg Spine. 35(4):446-453. doi:10.3171/2020.12.SPINE201890.

Spielmann J, Naujoks W, Emde M, Allweyer M, Fänder J, Kielstein H, Quandt D, Bähr I. (2021) The Impact of High-Fat Diet and Restrictive Feeding on Natural Killer Cells in Obese-Resistant BALB/c Mice. Front Nutr. 8:711824. doi:10.3389/fnut.2021.711824

Wu A, Maddula V, Singh J, Sagoo MG, Chien CL, Wingate R, Kielstein H, Traxler H, Brassett C, Waschke J, Vielmuth F, Sakurai T, Zeroual M, Olsen J, El-Batti S, Viranta-Kovanen S, Kitahara S, Keay K, Kunzel C, Bernd P, Noël GPJC. (2021) Alternatives to Student Outbound Mobility-Improving Students' Cultural Competency Skills Online to Improve Global Health Without Travel. Med Sci Educ. 31(4):1441-1451. doi: 10.1007/s40670-021-01332-9

Wu A, Maddula V, Yu ACX, Goel R, Shimizu H, Chien CL, Wingate R, Sagoo MG, Kielstein H, Traxler H, Brassett C, Waschke J, Vielmuth F, Keay K, Zeroual M, Sakurai T, Olsen J, El-Batti S, Viranta-Kovanen S, Kitahara S, Kunzel C, Bernd P, Noel GPJC. (2021) An Observation of Healthcare Professions Students' Perceptions During the COVID-19 Pandemic. Med Sci Educ. 31(2):401-409. doi: 10.1007/s40670-021-01240-y

Wu A, Yu ACX, Chang CS, Goel R, Sagoo MG, Sakurai T, Viranta-Kovanen S, Chien CL, Traxler H, Waschke J, Kitahara S, Keay K, Olsen J, Brassett C, Batti SE, Vielmuth F, Sigmund AM, Zeroual M, Kunzel C, Bernd P, Wingate R, Kielstein H, Noel GPJC. (2021) Initiating Students' Reflections on Life's Passing in the Anatomy Course - an International Observation at 14 Universities. Ann Anat. 237:151741. doi: 10.1016/j.aanat.2021.151741

Bähr I*, Spielmann J *, Quandt D, Kielstein H (2020) Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer. Front. Immunol. Review ARTICLE 11:245. doi:10.3389/fimmu.2020.00245 * These authors have contributed equally to this work.

Fuellen G, Liesenfeld O, Kowald A, Barrantes I, Bastian M, Simm A, Jansen L, Tietz-Latza A, Quandt D, Franceschi C, Walter M. (2020) The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging). Ageing Res Rev. 62:101091. doi:10.1016/j.arr.2020.101091. Review.

Gutteck N, Haase K, Kielstein H, Delank KS, Arnold C. (2020) Biomechanical results of percutaneous calcaneal osteotomy using two different osteotomy designs. Foot Ankle Surg. 26(5):551-555. doi:10.1016/j.fas.2019.07.004

Gutteck N, Schilde S, Reichel M, Holtz A, Sahmel O, Hinz P, Kielstein H, Lange J, Delank KS, Martin H. (2020) Posterolateral plate fixation with Pantalarlock® is more stable than nail fixation in tibiotalocalcaneal arthrodesis in a biomechanical cadaver study. Foot Ankle Surg. 26(3):328-333. doi:10.1016/j.fas.2019.04.006

Haase R, Reinhardt S, Rotzsch C, Kuehnoel C, Matschiner A. (2020) Mitral Valve Thrombosis in a Neonate: Thrombolysis with rTPA and Unfractionated Heparin. Ann Pediatr. 3(1): 1044

Naujoks W*, Quandt D*, Hauffe A, Kielstein H, Bähr I*, Spielmann J* (2020) Characterization of Surface Receptor Expression and Cytotoxicity of Human NK Cells and NK Cell Subsets in Overweight and Obese Humans. Front Immunol. 11:573200. doi:10.3389/fimmu.2020.573200 *These authors contributed equally to this work.

Rudolph K, Galvez C, Chang J, Wu A, Gölkel C, Sündermann SH, Kielstein H. (2020) Body donation as a grateful gift for a long and active life with a Björk-Shiley valve. J Card Surg. 35(10):2811-2813. doi:10.1111/jocs.14922

Schilde S, Ketelhut L, Kielstein H, Delank KS, Gutteck N. (2020) Anatomical study of Lapidus arthrodesis using two different plantar plate systems. Foot Ankle Surg. 26(5):585-590. doi:10.1016/j.fas.2019.07.016

Spielmann J, Mattheis L, Jung JS, Rauße H, Glaß M, Bähr I, Quandt D, Oswald J, Kielstein H. (2020) Effects of obesity on NK cells in a mouse model of postmenopausal breast cancer. Sci Rep. 10(1):20606. doi:10.1038/s41598-020-76906-5

Spielmann J, Naujoks W, Emde M, Allweyer M, Kielstein H, Quandt D*, Bähr I* (2020) High-Fat Diet and Feeding Regime Impairs Number, Phenotype, and Cytotoxicity of Natural Killer Cells in C57BL/6 Mice. Front. Nutr. 7:585693. doi:10.3389/fnut.2020.585693 *These authors have contributed equally to this work

Weihe P*, Spielmann J*, Kielstein H, Henning-Klusmann J, Weihrauch-Blüher S. (2020) Childhood Obesity and Cancer Risk in Adulthood. Curr Obes Rep . 9(3):204-212. doi:10.1007/s13679-020-00387-w. Review. *These authors contributed equally to this work.

Wu A, Noël GPJC, Wingate R, Kielstein H, Sakurai T, Viranta-Kovanen S, Chien CL, Traxler H, Waschke J, Vielmuth F, Sagoo MG, Kitahara S, Kato Y, Keay KA, Olsen J, Bernd P. (2020) An International Partnership of 12 Anatomy Departments - Improving Global Health through Internationalization of Medical Education. Ann Glob Health. 86(1):27. doi:10.5334/aogh.2665

Fänder J, Kielstein H, Büttner M, Koelblinger P, Dummer R, Bauer M, Handke D, Wickenhauser C, Seliger B, Jasinski-Bergner S. (2019) Characterizing CD44 regulatory microRNAs as putative therapeutic agents in human melanoma. Oncotarget. 10(60):6509-6525. doi:10.18632/oncotarget.27305

Gölkel C, Wu A, Chiuzan C, Duong J, Bernd P, Kielstein H. (2019) Early internationalization of students in a German medical school in the former German Democratic Republic. Ann Anat. 225:42-47. doi:10.1016/j.aanat.2019.03.004

Jasinski-Bergner S, Kielstein H. (2019) Adipokines Regulate the Expression of Tumor-Relevant MicroRNAs. Obes Facts. 12(2):211-225. doi:10.1159/000496625

Kielstein H, Fegerl I. (2019) Anna Morandi's successors. Lancet. 393(10182):1698. doi:10.1016/S0140-6736(18)33136-2

Kraya T*, Quandt D*, Pfirrmann T, Kindermann A, Lampe L, Schroeter ML, Kohlhase J, Stoevesandt D, Hoffmann K, Villavicencio-Lorini P. (2019) Functional characterization of a novel CSF1R mutation causing hereditary diffuse leukoencephalopathy with spheroids. Mol Genet Genomic Med. 7(4):e00595. doi:10.1002/mgg3.595
*These authors contributed equally to this work.

Lenz M, Schwinn J, Hofmann-Fliri L, Schwyn R, Knobe M, Klos K, Kielstein H, Hofmann GO, Gueorguiev B. (2019) Influence of reduced tip-apex distance on helical blade fixation - a biomechanical study. J Orthop Res. 37(3):649-654. doi:10.1002/jor.24202

Rothe K, Quandt D, Köhler G, Jasinski-Bergner S, Seliger B, Pierer M, Wagner U. (2019) IR-B expressing CD8+ T cells exhibit features of Tc1 and Tc17 in SKG mice.heumatology (Oxford). 58(12):2325-2329. doi:10.1093/rheumatology/kez256

Spielmann J, Bähr I, Naujoks W, Kielstein H, Quandt D. (2019) Natural killer cells, obesity and tumorigenesis. Adipositas. 13:36-42. doi:10.1055/a-0801-4014

Talty A, Deegan S, Ljujic M, Mnich K, Naicker SD, Quandt D, Zeng Q, Patterson JB, Gorman AM, Griffin MD, Samali A, Logue SE. (2019) Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β. Cell Death Dis. 10(9):622. doi:10.1038/s41419-019-1847-z

Wu A, Kielstein H, Sakurai T, Noel G, Viranta-Kovanen S, Chien CL, Bernd P. (2019) Internationalization of Medical Education—Building a Program to Prepare Future Leaders in Healthcare. Med.Sci.Educ. 29: 535-547. doi:10.1007/s40670-019-00695-4

Bähr I, Jahn J, Zipprich A, Pahlow I, Spielmann J, Kielstein H. (2018) Impaired natural killer cell subset phenotypes in human obesity. Immunologic Research. 66(2)234-244. doi:10.1007/s12026-018-8989-4

Fänder J, Büttner M, Kielstein H, Jasinski-Bergner S. (2018) A Missing Posterior Division of the Internal Iliac Artery. EJVES Short Rep. 40:18-20. doi:10.1016/j.ejvssr.2018.08.004

Grünberg M*, Quandt D*, Cynis H, Demuth HU, Kinderman A, Magdolen V, Forssmann WG, Seliger B, Mägert HJ. (2018) Kallikrein-related peptidases are activators of the CC chemokine CCL14. Eur J Immunol. 48(9):1592-1594. doi:10.1002/eji.201747452
*These authors contributed equally to this work.

Gutteck N, Martin H, Hanke T, Heilmann A, Kielstein H, Gradl G, Richter M, Delank KS, Wohlrab D. (2018) Posterolateral plate fixation with Talarlock® is more stable than screw fixation in ankle arthrodesis in a biomechanical cadaver study. Foot and Ankle Surgery. 24(3):208-212. doi:10.1016/j.fas.2017.02.005

Oswald J, Büttner M, Jasinski-Bergner S, Jacobs R, Rosenstock P, Kielstein H (2018) Leptin affects filopodia and cofilin in NK-92 cells in a dose- and time-dependent manner. European Journal of Histochemistry 62(1):2848. doi:10.4081/ejh.2018.2848

Winter F, Stoevesandt D, Schultka R, Viebig M, Moeller K, Steger F, Kielstein H. (2018) Bodies of children in the Institute of Anatomy in Halle (Saale), Germany, between 1920 and 1945. Ann Anat. 215:40-46. doi:10.1016/j.aanat.2017.09.005

Bähr I, Goritz V, Doberstein H, GGR Hiller, Rosenstock P, Jahn J, Pörtner O, Berreis T, Mueller T, Spielmann J, Kielstein H. (2017) Diet-induced obesity is associated with an impaired NK cell function and an increased colon cancer incidence. J Nutr Metab. 2017:4297025. doi:10.1155/2017/4297025

Jasinski-Bergner S, Büttner M, Quandt D, Seliger B, Kielstein H. (2017) Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin. Obes Facts. 10(6):569-583. doi:10.1159/000481732

Jasinski-Bergner S, Radetzki A.-L., Jahn J, Wohlrab D, Kielstein H. (2017) Impact of the body mass index on perioperative immunological disturbances in patients with hip and knee arthroplasty. J Orthop Surg Res. 12(1):58. doi:10.1186/s13018-017-0557-4

Hiller RG, Patecki M, Neunaber C, Reifenrath J, Kielstein JT, Kielstein H. (2017) A comparative study of bone biopsies from the iliac crest, the tibial bone, and the lumbar spine. BMC Nephrol. 18(1):134. doi:10.1186/s12882-017-0550-5

Rosenstock P, Horstkorte R, Gnanapragassam VS, Harth J, Kielstein H. (2017) Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans. Immunol Res. 65(5): 1017-1024. doi:10.1007/s12026-017-8942-y

Spielmann J, Hanke J, Knauf D, Ben-Eliyahu S, Jacobs R, Stangl GI, Bähr I, Kielstein H. (2017) Significantly enhanced lung metastasis and reduced organ NK cell functions in diet-induced obese rats. BMC Obesity 4:24. doi:10.1186/s40608-017-0161-5

Yussif A-S, Lassey A, Ganyaglo G Y-k, Kantelhardt EJ, Kielstein H (2017) The long-term effects of adolescent pregnancies in a community in Northern Ghana on subsequent pregnancies and births of the young mothers. Reproductive Health 14(1):178. doi:10.1186/s12978-017-0443-x

Jasinski-Bergner S, Reches A, Stoehr C, Massa C, Gonschorek E, Huettelmaier S, Braun J, Wach S, Wullich B, Spath V, Wang E, Marincola FM, Mandelboim O, Hartmann A, Seliger B. (2016) Identification of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma. Oncotarget. 7(18):26866-78.

Lenz M, Stoffel K, Gueorguiev B, Kielstein H, Hofmann GO. (2016) Enhancing fixation strength in periprosthetic femur fractures by orthogonal plating - a biomechanical study. J Orthop Res. 34(4):591-6.

Lenz M, Stoffel K, Kielstein H, Mayo K, Hofmann GO, Gueorguiev B. (2016) Plate fixation in periprosthetic femur fractures Vancouver type B1—Trochanteric hook plate or subtrochanterical bicortical locking? Injury. 47(12):2800-4.

Mattheis L, Jung J-S, Hiebl B, Garrels W, Kielstein H, Spielmann J. (2016) Perioperative support reduces mortality of obese BALB/c mice after ovariectomy. Lab Animal. 45(7):262-7.

Rothe K, Quandt D, Schubert K, Rossol M, Klingner M, Jasinski-Bergner S, Scholz R, Seliger B, Pierer M, Baerwald C, Wagner U. (2016) Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of cytolytic LIR-1+ CD8+ T Cells. Arthritis Rheumatol. 68(2):337-46.

Scheurer J, Stoevesandt D, Siekmann H, Kielstein, H. (2016) The tell-tale thigh. BMJ Case reports. pii:bcr2015212909.

Schwimmer-Okike N, Niebuhr J, Schramek GG, Frantz S, Kielstein H.(2016) The Presence of a Large Chiari Network in a Patient with Atrial Fibrillation and Stroke. Case Rep Cardiol. 2016:4839315.

Seliger B, Jasinski-Bergner S, Quandt D, Stoehr C, Bukur J, Wach S, Legal W, Taubert H, Wullich B, Hartmann A. (2016) HLA-E expression and its clinical relevance in human renal cell carcinoma. Oncotarget. 7(41):67360-72.

Skopp A, May M, Janke J, Kielstein H, Wunder R, Flade-Kuthe R, Kuthe A, Jordan J, Engeli S (2016) Regulation of G0/G1 Switch Gene 2 (G0S2) expression in human adipose tissue. Arch Physiol Biochem. 122(2):47-53.