2022
Chehade L, Deguise M-O, De Repentigny Y, Yaworski R, Beauvais A, Gagnon S, Hensel N, Kothary, R. (2022) Suppression of the necroptotic cell death pathways improves survival in Smn 2B/- mice. Front Cell Neurosci. 16:972029. doi: 10.3389/fncel.2022.972029
Detering NT, Schüning T, Hensel N, Claus P. (2022) The phospho-landscape of the survival of motoneuron protein (SMN) protein: relevance for spinal muscular atrophy (SMA). Cell Mol Life Sci. 79(9):497. doi: 10.1007/s00018-022-04522-9
Detering NT, Zambon A, Hensel N, Kothary R, Swoboda K, Gillingwater TH, Baranello G; Workshop participants; Industry participants. (2022) 264th ENMC International Workshop: Multi-system involvement in spinal muscular atrophy Hoofddorp, the Netherlands, November 19th - 21st 2021. Neuromuscul Disord. 32(8):697-705. doi: 10.1016/j.nmd.2022.06.005
Reilly A, Deguise M-O, Beauvais A, Yaworski R, Thebault S, Tessier DR, Tabard-Cossa V, Hensel N, Schneider BL, Kothary R. (2022) Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy. Gene Ther. 29(9):544-554. doi: 10.1038/s41434-022-00338-1
2021
Bora G, Hensel N, Rademacher S, Koyunoğlu D, Sunguroğlu M, Aksu-Mengeş E, Balcı-Hayta B, Claus P, Erdem-Yurter H. (2021) Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy. Hum Mol Genet. 29(24):3935-3944. doi: 10.1093/hmg/ddaa275
Hensel N, Cieri F, Santonicola P, Tapken I, Schüning T, Taiana M, Pagliari E, Joseph A, Fischer S, Heidrich N, Brinkmann H, Kubinski S, Bergmann AK, Richter MF, Jung K, Corti S, Di Schiavi E*, Claus P*. (2021) Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in spinal muscular atrophy. Proc Natl Acad Sci U S A. 118(18):e2007785118. doi: 10.1073/pnas.2007785118. *These authors contributed equally to this work.
2020
Allardyce H, Kuhn D, Hernandez-Gerez E, Hensel N, Huang Y-T, Faller K, Gillingwater TH, Quondamatteo F, Claus P, Parson SH. (2020) Renal pathology in a mouse model of severe Spinal Muscular Atrophy is associated with downregulation of Glial Cell-Line Derived Neurotrophic Factor (GDNF). Hum Mol Genet. 29(14):2365-2378. doi: 10.1093/hmg/ddaa126
Hensel N, Brickwedde H, Tsaknakis K, Grages A, Braunschweig L, Lüders KA, Lorenz HM, Lippross S, Walter LM, Tavassol F, Lienenklaus S, Neunaber C, Claus P, Hell AK. (2020) Altered bone development with impaired cartilage formation precedes neuromuscular symptoms in spinal muscular atrophy. Hum Mol Genet. 29(16):2662-2673. doi: 10.1093/hmg/ddaa145
Hensel N, Detering NT, Walter LM, Claus P. (2020) Resolution of pathogenic R-loops rescues motor neuron degeneration in spinal muscular atrophy. Brain. 143(1):2-5. doi: 10.1093/brain/awz394
Hensel N, Kubinski S, Claus P. (2020) The Need for SMN-Independent Treatments of Spinal Muscular Atrophy (SMA) to Complement SMN-Enhancing Drugs. Front Neurol. 11:45. doi: 10.3389/fneur.2020.00045
Hensel N, Raker V, Förthmann B, Buch A, Sodeik B, Pich A, Claus P. (2020) The Proteome and Secretome of Cortical Brain Cells Infected With Herpes Simplex Virus. Front Neurol. 11:844. doi: 10.3389/fneur.2020.00844
Walter LM, Franz P, Lindner R, Tsiavaliaris G, Hensel N*, Claus P*. (2020) Profilin2a-phosphorylation as a regulatory mechanism for actin dynamics. FASEB J. 34(2):2147-2160. doi: 10.1096/fj.201901883R. *These authors contributed equally to this work.
2019
Bursch F, Kalmbach N, Naujock M, Staege S, Eggenschwiler R, Abo-Rady M, Japtok J, Guo W, Hensel N, Reinhardt P, Boeckers TM, Cantz T, Sterneckert J, Van Den Bosch L, Hermann A, Petri S, Wegner F. (2019) Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations. Hum Mol Genet. 28(17):2835-2850. doi: 10.1093/hmg/ddz107
Hensel N*, Raker V*, Förthmann B, Detering NT, Kubinski S, Buch A, Katzilieris-Petras G, Spanier J, Gudi V, Wagenknecht S, Kopfnagel V, Werfel TA, Stangel M, Beineke A, Kalinke U, Paludan SR, Sodeik B, Claus P. (2019) HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0. J Neuroinflammation. 16(1):248. doi: 10.1186/s12974-019-1647-5. *These authors contributed equally to this work.
2018
Hensel N, Claus P. (2018) The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration? Neuroscientist. 24(1):54-72. doi: 10.1177/1073858417705059
Uhde AK, Ciurkiewicz M, Herder V, Khan MA, Hensel N, Claus P, Beckstette M, Teich R, Floess S, Baumgärtner W, Jung K, Huehn J, Beineke A. (2018) Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice. Sci Rep. 8(1):6106. doi: 10.1038/s41598-018-24378-z
2017
Hensel N, Baskal S, Walter LM, Brinkmann H, Gernert M, Claus P. (2017) ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy. Neurobiol Dis. 108:352-361. doi: 10.1016/j.nbd.2017.09.005
Rademacher S, Verheijen BM, Hensel N, Peters M, Bora G, Brandes G, Vieira de Sá R, Heidrich N, Fischer S, Brinkmann H, van der Pol WL, Wirth B, Pasterkamp RJ, Claus P. (2017) Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA). Hum Mol Genet. 26(20):3946-3959. doi: 10.1093/hmg/ddx282
2016
Hensel N, Schön A, Konen T, Lübben V, Förthmann B, Baron O, Grothe C, Leifheit-Nestler M, Claus P, Haffner D. (2016) Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density. J Neurochem. 137(5):756-69. doi: 10.1111/jnc.13585
Stanslowsky N, Reinhardt P, Glass H, Kalmbach N, Naujock M, Hensel N, Lübben V, Pal A, Venneri A, Lupo F, De Franceschi L, Claus P, Sterneckert J, Storch A, Hermann A, Wegner F. (2016) Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization. J Neurosci. 36(47):12027-12043. doi: 10.1523/JNEUROSCI.0456-16.2016