A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.
Hartlage-Rübsamen M, Bluhm A, Moceri S, Machner L, Köppen J, Schenk M, Hilbrich I, Holzer M, Weidenfeller M, Richter F, Coras R, Serrano GE, Beach TG, Schilling S, von Hörsten S, Xiang W, Schulze A, Roßner S.
Acta Neuropathol. 2021 Sep;142(3):399-421. doi: 10.1007/s00401-021-02349-5. Epub 2021 Jul 26.
PMID: 34309760
Macromolecular Crowding Induces a Binding Competent Transient Structure in Intrinsically Disordered Gab1.
Gruber T, Lewitzky M, Machner L, Weininger U, Feller SM, Balbach J.
J Mol Biol. 2022 Mar 15;434(5):167407. doi: 10.1016/j.jmb.2021.167407. Epub 2021 Dec 17.
PMID: 34929201
A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding.
Bernegger S, Brunner C, Vizovišek M, Fonovic M, Cuciniello G, Giordano F, Stanojlovic V, Jarzab M, Simister P, Feller SM, Obermeyer G, Posselt G, Turk B, Cabrele C, Schneider G, Wessler S.
Sci Rep. 2020 Jun 29;10(1):10563. doi: 10.1038/s41598-020-67578-2.
PMID: 32601479
The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner.
Bongartz H, Gille K, Hessenkemper W, Mandel K, Lewitzky M, Feller SM, Schaper F.
Cell Commun Signal. 2019 Oct 24;17(1):135. doi: 10.1186/s12964-019-0451-2.
PMID: 31651330
The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells.
Bongartz H, Hessenkemper W, Müller C, Fensky M, Fritsch J, Mandel K, Behrmann I, Haan C, Fischer T, Feller SM, Schaper F.
Cell Signal. 2017 Jul;35:37-47. doi: 10.1016/j.cellsig.2017.03.021. Epub 2017 Mar 30.
PMID: 28365441
Pharmacoproteomic characterisation of human colon and rectal cancer.
Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, Ruprecht B, Meng C, Kramer K, Jarzab A, Heinzlmeir S, Johnstone E, Domingo E, Kerr D, Jesinghaus M, Slotta-Huspenina J, Weichert W, Knapp S, Feller SM, Kuster B.
Mol Syst Biol. 2017 Nov 3;13(11):951. doi: 10.15252/msb.20177701.
PMID: 29101300
Hunting for the ultimate liquid cancer biopsy - let the TEP dance begin.
Feller SM, Lewitzky M.
Cell Commun Signal. 2016 Sep 27;14(1):24. doi: 10.1186/s12964-016-0147-9.
PMID: 27677261
Quantitative imaging for development of companion diagnostics to drugs targeting HGF/MET.
Huang F, Ma Z, Pollan S, Yuan X, Swartwood S, Gertych A, Rodriguez M, Mallick J, Bhele S, Guindi M, Dhall D, Walts AE, Bose S, de Peralta Venturina M, Marchevsky AM, Luthringer DJ, Feller SM, Berman B, Freeman MR, Alvord WG, Vande Woude G, Amin MB, Knudsen BS.
J Pathol Clin Res. 2016 Jul 1;2(4):210-222. doi: 10.1002/cjp2.49. eCollection 2016 Oct.
PMID: 27785366
LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.
Kramer HB, Lai CF, Patel H, Periyasamy M, Lin ML, Feller SM, Fuller-Pace FV, Meek DW, Ali S, Buluwela L.
Nucleic Acids Res. 2016 Jan 29;44(2):582-94. doi: 10.1093/nar/gkv948. Epub 2015 Sep 22.
PMID: 26400164
A THEMIS:SHP1 complex promotes T-cell survival.
Paster W, Bruger AM, Katsch K, Grégoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, Acuto O.
EMBO J. 2015 Feb 3;34(3):393-409. doi: 10.15252/embj.201387725. Epub 2014 Dec 22.
PMID: 25535246
Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.
Stoepker C, Ameziane N, van der Lelij P, Kooi IE, Oostra AB, Rooimans MA, van Mil SE, Brink A, Dietrich R, Balk JA, Ylstra B, Joenje H, Feller SM, Brakenhoff RH.
Cancer Res. 2015 Sep 1;75(17):3543-53. doi: 10.1158/0008-5472.CAN-15-0528. Epub 2015 Jun 29.
PMID: 26122845
Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
Rouka E, Simister PC, Janning M, Kumbrink J, Konstantinou T, Muniz JR, Joshi D, O'Reilly N, Volkmer R, Ritter B, Knapp S, von Delft F, Kirsch KH, Feller SM.
J Biol Chem. 2015 Oct 16;290(42):25275-92. doi: 10.1074/jbc.M115.637207. Epub 2015 Aug 20.
PMID: 26296892
MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.
Wolf A, Eulenfeld R, Bongartz H, Hessenkemper W, Simister PC, Lievens S, Tavernier J, Feller SM, Schaper F.
Cell Signal. 2015 Feb;27(2):340-52. doi: 10.1016/j.cellsig.2014.11.017. Epub 2014 Nov 25.
PMID: 25460044
Conformational recognition of an intrinsically disordered protein.
Krieger JM, Fusco G, Lewitzky M, Simister PC, Marchant J, Camilloni C, Feller SM, De Simone A.
Biophys J. 2014 Apr 15;106(8):1771-9. doi: 10.1016/j.bpj.2014.03.004.
PMID: 24739176
Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling.
Gao S, Bajrami I, Verrill C, Kigozi A, Ouaret D, Aleksic T, Asher R, Han C, Allen P, Bailey D, Feller S, Kashima T, Athanasou N, Blay JY, Schmitz S, Machiels JP, Upile N, Jones TM, Thalmann G, Ashraf SQ, Wilding JL, Bodmer WF, Middleton MR, Ashworth A, Lord CJ, Macaulay VM.
Cancer Res. 2014 Oct 15;74(20):5866-77. doi: 10.1158/0008-5472.CAN-14-0806. Epub 2014 Aug 28.
PMID: 25168481
Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site.
Perna AM, Reisen F, Schmidt TP, Geppert T, Pillong M, Weisel M, Hoy B, Simister PC, Feller SM, Wessler S, Schneider G.
Chem Sci. 2014 Jun 30;5:3583-3590. doi: 10.1039/C4SC01443J.
PMID: 26819700
Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.
Lourenço FC, Munro J, Brown J, Cordero J, Stefanatos R, Strathdee K, Orange C, Feller SM, Sansom OJ, Vidal M, Murray GI, Olson MF.
Gut. 2014 Mar;63(3):480-93. doi: 10.1136/gutjnl-2012-303883. Epub 2013 Apr 12.
PMID: 23585469
ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63.
Tordella L, Koch S, Salter V, Pagotto A, Doondeea JB, Feller SM, Ratnayaka I, Zhong S, Goldin RD, Lozano G, McKeon FD, Tavassoli M, Fritzsche F, Huber GF, Rössle M, Moch H, Lu X.
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17969-74. doi: 10.1073/pnas.1309362110. Epub 2013 Oct 14.
PMID: 24127607
Excellence in cell signaling research recognized with major new award.
Feller SM.
Cell Commun Signal. 2013 Mar 4;11(1):17. doi: 10.1186/1478-811X-11-17.
PMID: 23497077
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
Paster W, Brockmeyer C, Fu G, Simister PC, de Wet B, Martinez-Riaño A, Hoerter JA, Feller SM, Wülfing C, Gascoigne NR, Acuto O.
J Immunol. 2013 Apr 1;190(7):3749-56. doi: 10.4049/jimmunol.1203389. Epub 2013 Mar 4.
PMID: 23460737
Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.
Sato S, Zhao Y, Imai M, Simister PC, Feller SM, Trackman PC, Kirsch KH, Sonenshein GE.
PLoS One. 2013 Oct 22;8(10):e77288. doi: 10.1371/journal.pone.0077288. eCollection 2013.
PMID: 24167568
Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.
Benz PM, Merkel CJ, Offner K, Abeßer M, Ullrich M, Fischer T, Bayer B, Wagner H, Gambaryan S, Ursitti JA, Adham IM, Linke WA, Feller SM, Fleming I, Renné T, Frantz S, Unger A, Schuh K.
Cell Commun Signal. 2013 Aug 12;11:56. doi: 10.1186/1478-811X-11-56.
PMID: 23937664
Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.
Simister PC, Luccarelli J, Thompson S, Appella DH, Feller SM, Hamilton AD.
Bioorg Med Chem. 2013 Jul 15;21(14):4027-33. doi: 10.1016/j.bmc.2012.10.023. Epub 2012 Oct 27.
PMID: 23182216
Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines.
Rose HM, Stuiver M, Thongwichian R, Theillet FX, Feller SM, Selenko P.
Biochim Biophys Acta. 2013 Jul;1834(7):1396-401. doi: 10.1016/j.bbapap.2013.01.023. Epub 2013 Jan 27.
PMID: 23360766
Tony (Anthony James) Pawson, a giant in the field of cell signaling research, dies unexpectedly at the age of 60. Feller SM
Cell Communication and Signaling, 11: 61.
Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks.
Lewitzky M, Simister PC, Feller SM.
FEBS Lett. 2012 Aug 14;586(17):2740-50. doi: 10.1016/j.febslet.2012.04.029. Epub 2012 Apr 25.
PMID: 22710161
Microproteins (miPs) - the next big thing.
Feller S.
Cell Commun Signal. 2012 Dec 18;10(1):42. doi: 10.1186/1478-811X-10-42.
PMID: 23249432
Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns.
Schuh A, Becq J, Humphray S, Alexa A, Burns A, Clifford R, Feller SM, Grocock R, Henderson S, Khrebtukova I, Kingsbury Z, Luo S, McBride D, Murray L, Menju T, Timbs A, Ross M, Taylor J, Bentley D.
Blood. 2012 Nov 15;120(20):4191-6. doi: 10.1182/blood-2012-05-433540. Epub 2012 Aug 22.
PMID: 22915640
Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies.
Simister PC, Feller SM.
Mol Biosyst. 2012 Jan;8(1):33-46. doi: 10.1039/c1mb05272a. Epub 2011 Sep 20.
PMID: 21935523
Phosphotyrosine recognition domains: the typical, the atypical and the versatile.
Kaneko T, Joshi R, Feller SM, Li SS.
Cell Commun Signal. 2012 Nov 7;10(1):32. doi: 10.1186/1478-811X-10-32.
PMID: 23134684
Science, democracy and emerging threats to scientific progress.
Feller SM.
Cell Commun Signal. 2012 Aug 23;10(1):24. doi: 10.1186/1478-811X-10-24.
PMID: 22916710
Very 'sticky' proteins - not too sticky after all?
Feller SM, Lewitzky M.
Cell Commun Signal. 2012 Jun 14;10(1):15. doi: 10.1186/1478-811X-10-15.
PMID: 22697256
What's in a loop?
Feller SM, Lewitzky M.
Cell Commun Signal. 2012 Oct 30;10(1):31. doi: 10.1186/1478-811X-10-31.
PMID: 23110718
Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides.
Liu F, Giubellino A, Simister PC, Qian W, Giano MC, Feller SM, Bottaro DP, Burke TR Jr.
Biopolymers. 2011;96(6):780-8. doi: 10.1002/bip.21692.
PMID: 21830199
Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.
Ehsanian R, Van Waes C, Feller SM.
Cell Commun Signal. 2011 May 15;9:13. doi: 10.1186/1478-811X-9-13.
PMID: 21569639
First Honorary Medal of the Signal Transduction Society (STS) and 'CELL COMMUNICATION AND SIGNALING' awarded to Professor Anthony J. (Tony) Pawson.
Feller SM.
Cell Commun Signal. 2011 Jan 19;9(1):3. doi: 10.1186/1478-811X-9-3.
PMID: 21247454
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.
Wu Z, Doondeea JB, Gholami AM, Janning MC, Lemeer S, Kramer K, Eccles SA, Gollin SM, Grenman R, Walch A, Feller SM, Kuster B.
Mol Cell Proteomics. 2011 Dec;10(12):M111.011635. doi: 10.1074/mcp.M111.011635. Epub 2011 Sep 28.
PMID: 21955398
Science under the lamppost.
Feller SM.
Cell Commun Signal. 2011 Sep 22;9:21. doi: 10.1186/1478-811X-9-21.
PMID: 21939516
Self-organization and regulation of intrinsically disordered proteins with folded N-termini.
Simister PC, Schaper F, O'Reilly N, McGowan S, Feller SM.
PLoS Biol. 2011 Feb 15;9(2):e1000591. doi: 10.1371/journal.pbio.1000591.
PMID: 21347241
Beyond journal impact factors?
Feller SM.
Cell Commun Signal. 2010 Mar 10;8(1):4. doi: 10.1186/1478-811X-8-4.
PMID: 20219121
Early beginnings - the emergence of complex signaling systems and cell-to-cell communication.
Feller SM.
Cell Commun Signal. 2010 Jul 12;8:16. doi: 10.1186/1478-811X-8-16.
PMID: 20624299
High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells.
Kress TR, Raabe T, Feller SM.
Cell Commun Signal. 2010 Feb 2;8(1):1. doi: 10.1186/1478-811X-8-1.
PMID: 20181064
Life v2.0 - Quo vadis Homo sapiens?
Feller SM.
Cell Commun Signal. 2010 Jun 4;8:9. doi: 10.1186/1478-811X-8-9.
PMID: 20525343
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Hävemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF.
J Virol. 2010 Aug;84(16):8231-40. doi: 10.1128/JVI.01696-09. Epub 2010 Jun 9.
PMID: 20534855
Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.
Kroczek C, Lang C, Brachs S, Grohmann M, Dütting S, Schweizer A, Nitschke L, Feller SM, Jäck HM, Mielenz D.
J Immunol. 2010 Apr 1;184(7):3665-76. doi: 10.4049/jimmunol.0903642. Epub 2010 Mar 1.
PMID: 20194721
The dawn of a new era in cell signalling research.
Feller SM.
Cell Commun Signal. 2010 May 24;8(1):7. doi: 10.1186/1478-811X-8-7.
PMID: 20497528
YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets.
Ehsanian R, Brown M, Lu H, Yang XP, Pattatheyil A, Yan B, Duggal P, Chuang R, Doondeea J, Feller S, Sudol M, Chen Z, Van Waes C.
Oncogene. 2010 Nov 18;29(46):6160-71. doi: 10.1038/onc.2010.339. Epub 2010 Aug 23.
PMID: 20729916
Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.
Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S.
Cell Res. 2009 May;19(5):638-50. doi: 10.1038/cr.2009.40.
PMID: 19350053
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.
Harkiolaki M, Tsirka T, Lewitzky M, Simister PC, Joshi D, Bird LE, Jones EY, O'Reilly N, Feller SM.
Structure. 2009 Jun 10;17(6):809-22. doi: 10.1016/j.str.2009.03.017.
PMID: 19523899
Obituary: hidesaburo hanafusa 1929-2009.
Feller SM.
Cell Commun Signal. 2009 Apr 20;7:7. doi: 10.1186/1478-811X-7-7.
PMID: 19379504
Signal transduction in the footsteps of goethe and schiller.
Friedrich K, Lindquist JA, Entschladen F, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R.
Cell Commun Signal. 2009 Feb 4;7:2. doi: 10.1186/1478-811X-7-2.
PMID: 19193215
Signal transduction--receptors, mediators, and genes.
Entschladen F, Lindquist JA, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R, Friedrich K.
Sci Signal. 2009 Mar 24;2(63):mr3. doi: 10.1126/scisignal.263mr3.
PMID: 19318619
Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.
Brady SC, Coleman ML, Munro J, Feller SM, Morrice NA, Olson MF.
Cancer Res. 2009 Sep 1;69(17):6773-81. doi: 10.1158/0008-5472.CAN-08-4447. Epub 2009 Aug 18.
PMID: 19690147
Cell Communication and Signaling is becoming the official journal of the Signal Transduction Society.
Feller SM, Hass R, Janssen O, Friedrich K.
Cell Commun Signal. 2008 Aug 6;6:1. doi: 10.1186/1478-811X-6-1.
PMID: 18680612
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Emaduddin M, Bicknell DC, Bodmer WF, Feller SM.
Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2358-62. doi: 10.1073/pnas.0712176105. Epub 2008 Feb 7.
PMID: 18258742
Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes.
Benz PM, Blume C, Moebius J, Oschatz C, Schuh K, Sickmann A, Walter U, Feller SM, Renné T.
J Cell Biol. 2008 Jan 14;180(1):205-19. doi: 10.1083/jcb.200709181.
PMID: 18195108
Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
Backert S, Feller SM, Wessler S.
Trends Biochem Sci. 2008 Feb;33(2):80-90. doi: 10.1016/j.tibs.2007.10.006. Epub 2008 Jan 7.
PMID: 18182299
Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells.
Aleksic T, Feller SM.
Cell Commun Signal. 2008 Oct 24;6:8. doi: 10.1186/1478-811X-6-8.
PMID: 18950493
Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells.
Emaduddin M, Edelmann MJ, Kessler BM, Feller SM.
Cell Commun Signal. 2008 Oct 9;6:7. doi: 10.1186/1478-811X-6-7.
PMID: 18844995
Prostaglandin-induced VASP phosphorylation controls alpha II-spectrin breakdown in apoptotic cells.
Benz PM, Feller SM, Sickmann A, Walter U, Renné T.
Int Immunopharmacol. 2008 Feb;8(2):319-24. doi: 10.1016/j.intimp.2007.10.004. Epub 2007 Oct 24.
PMID: 18182247
Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo.
Niendorf S, Oksche A, Kisser A, Löhler J, Prinz M, Schorle H, Feller S, Lewitzky M, Horak I, Knobeloch KP.
Mol Cell Biol. 2007 Jul;27(13):5029-39. doi: 10.1128/MCB.01566-06. Epub 2007 Apr 23.
PMID: 17452457
Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility.
Poppe M, Feller SM, Römer G, Wessler S.
Oncogene. 2007 May 24;26(24):3462-72. doi: 10.1038/sj.onc.1210139. Epub 2006 Dec 11.
PMID: 17160020
Molecular profiling of signalling proteins for effects induced by the anti-cancer compound GSAO with 400 antibodies.
Cadd VA, Hogg PJ, Harris AL, Feller SM.
BMC Cancer. 2006 Jun 9;6:155. doi: 10.1186/1471-2407-6-155.
PMID: 16764713
Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors.
Feller SM, Lewitzky M.
Curr Pharm Des. 2006;12(5):529-48. doi: 10.2174/138161206775474369.
PMID: 16472145
The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal.
Harkiolaki M, Gilbert RJ, Jones EY, Feller SM.
Structure. 2006 Dec;14(12):1741-53. doi: 10.1016/j.str.2006.09.013.
PMID: 17161365
Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix.
Lewitzky M, Harkiolaki M, Domart MC, Jones EY, Feller SM.
J Biol Chem. 2004 Jul 2;279(27):28724-32. doi: 10.1074/jbc.M402745200. Epub 2004 Apr 20.
PMID: 15100220
PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors.
Schmidt EK, Fichelson S, Feller SM.
BMC Biol. 2004 May 18;2:7. doi: 10.1186/1741-7007-2-7.
PMID: 15149544
Rap1 regulates the formation of E-cadherin-based cell-cell contacts.
Hogan C, Serpente N, Cogram P, Hosking CR, Bialucha CU, Feller SM, Braga VM, Birchmeier W, Fujita Y.
Mol Cell Biol. 2004 Aug;24(15):6690-700. doi: 10.1128/MCB.24.15.6690-6700.2004.
PMID: 15254236
High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.
Feller SM, Tuchscherer G, Voss J.
Leuk Lymphoma. 2003 Mar;44(3):411-27. doi: 10.1080/1042819021000037930.
PMID: 12688310
Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76.
Harkiolaki M, Lewitzky M, Gilbert RJ, Jones EY, Bourette RP, Mouchiroud G, Sondermann H, Moarefi I, Feller SM.
EMBO J. 2003 Jun 2;22(11):2571-82. doi: 10.1093/emboj/cdg258.
PMID: 12773374
SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases.
Feller SM, Wecklein H, Lewitzky M, Kibler E, Raabe T.
Mech Dev. 2002 Aug;116(1-2):129-39. doi: 10.1016/s0925-4773(02)00147-8.
PMID: 12128212
Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck.
Schweimer K, Hoffmann S, Bauer F, Friedrich U, Kardinal C, Feller SM, Biesinger B, Sticht H.
Biochemistry. 2002 Apr 23;41(16):5120-30. doi: 10.1021/bi015986j.
PMID: 11955060
Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes.
Kardinal C, Konkol B, Lin H, Eulitz M, Schmidt EK, Estrov Z, Talpaz M, Arlinghaus RB, Feller SM.
Blood. 2001 Sep 15;98(6):1773-81. doi: 10.1182/blood.v98.6.1773.
PMID: 11535511
Crk family adaptors-signalling complex formation and biological roles.
Feller SM.
Oncogene. 2001 Oct 1;20(44):6348-71. doi: 10.1038/sj.onc.1204779.
PMID: 11607838
Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.
Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O.
FEBS Lett. 2001 Dec 7;509(2):255-62. doi: 10.1016/s0014-5793(01)03174-x.
PMID: 11741599
Targeting Molecular Recognition: Exploring the Dual Role of Functional Pseudoprolines in the Design of SH3 Ligands This work was supported by the Swiss National Science Foundation.
Tuchscherer G, Grell D, Tatsu Y, Durieux P, Fernandez-Carneado J, Hengst B, Kardinal C, Feller S.
Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2844-2848.
PMID: 11500884
The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.
Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM.
Oncogene. 2001 Mar 1;20(9):1052-62. doi: 10.1038/sj.onc.1204202.
PMID: 11314042
Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients.
Kardinal C, Konkol B, Schulz A, Posern G, Lin H, Adermann K, Eulitz M, Estrov Z, Talpaz M, Arlinghaus RB, Feller SM.
FASEB J. 2000 Aug;14(11):1529-38. doi: 10.1096/fj.14.11.1529.
PMID: 10928987
Characterization of Ggrb4, an adapter protein interacting with Bcr-Abl.
Coutinho S, Jahn T, Lewitzky M, Feller S, Hutzler P, Peschel C, Duyster J.
Blood. 2000 Jul 15;96(2):618-24.
PMID: 10887126
Rapid lamellipodia formation in nerve growth factor-stimulated PC12 cells is dependent on Rac and PI3K activity.
Posern G, Saffrich R, Ansorge W, Feller SM.
J Cell Physiol. 2000 Jun;183(3):416-24. doi: 10.1002/(SICI)1097-4652(200006)183:3<416::AID-JCP15>3.0.CO;2-R.
PMID: 10797317
Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes.
Schmidt M, Goebeler M, Posern G, Feller SM, Seitz CS, Brocker EB, Rapp UR, Ludwig S.
J Biol Chem. 2000 Dec 29;275(52):41011-7. doi: 10.1074/jbc.M003716200.
PMID: 11018025
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.
Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM.
J Biol Chem. 2000 Apr 14;275(15):10772-8. doi: 10.1074/jbc.275.15.10772.
PMID: 10753869
The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss 3T3 cells.
Posern G, Rapp UR, Feller SM.
Oncogene. 2000 Dec 14;19(54):6361-8. doi: 10.1038/sj.onc.1204027.
PMID: 11175351
The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways.
Voss J, Posern G, Hannemann JR, Wiedemann LM, Turhan AG, Poirel H, Bernard OA, Adermann K, Kardinal C, Feller SM.
Oncogene. 2000 Mar 23;19(13):1684-90. doi: 10.1038/sj.onc.1203467.
PMID: 10763825
Tumor-derived mutated E-cadherin influences beta-catenin localization and increases susceptibility to actin cytoskeletal changes induced by pervanadate.
Luber B, Candidus S, Handschuh G, Mentele E, Hutzler P, Feller S, Voss J, Höfler H, Becker KF.
Cell Adhes Commun. 2000 May;7(5):391-408. doi: 10.3109/15419060009109021.
PMID: 10830618